The University of Osaka · Medicine
Professor Akito Nakagawa's research lab focuses on the pathophysiology and clinical outcomes of heart failure with preserved ejection fraction (HFpEF), with a particular emphasis on right ventricular and pulmonary vascular dysfunction. The lab investigates molecular mechanisms such as Wnt/β-catenin signaling in endothelial cells and their impact on cardiac function, as well as hemodynamic markers like pulmonary arterial capacitance and right ventricular-pulmonary artery uncoupling. Using prospective, multicenter observational studies, the lab aims to identify prognostic biomarkers and clinical phenotypes to guide personalized management in elderly HFpEF patients. Their work bridges basic vascular biology with clinical cardiology to improve outcomes in this high-risk population.
Figures are computed from collected data and may differ slightly.
Prospective study of a hospitalized cohort revealed that RV-PA uncoupling was independently associated with adverse outcomes in acute decompensated patients with HFpEF. Registration: URL: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000024414. Unique identifier: UMIN000021831.
Activation of β-catenin-dependent canonical Wnt signaling in endothelial cells plays a key role in angiogenesis during development and ischemic diseases, however, other roles of Wnt/β-catenin signaling in endothelial cells remain poorly understood. Here, we report that sustained activation of β-catenin signaling in endothelial cells causes cardiac dysfunction through suppressing neuregulin-ErbB pathway in the heart. Conditional gain-of-function mutation of β-catenin, which activates Wnt/β-cateni
Background Although the prognostic importance of pulmonary arterial capacitance (PAC; stroke volume/pulmonary arterial pulse pressure) has been elucidated in heart failure with reduced ejection fraction, whether its significance in patients suffering from heart failure with preserved ejection fraction is not known. We aimed to examine the association of PAC with outcomes in inpatients with heart failure with preserved ejection fraction. Methods and Results We prospectively studied 705 patients (
Higher plasma osmolality on admission was prognostically important for acute decompensated HFpEF inpatients.
Background Although potential therapeutic candidates for heart failure with preserved ejection fraction (HFpEF) are emerging, it is still unclear whether they will be effective in patients with left ventricular ejection fraction (LVEF) of 60% or higher. Our aim was to identify the clinical characteristics of these patients with HFpEF by comparing them to patients with LVEF below 60%. Methods and Results From a multicenter, prospective, observational cohort (PURSUIT-HFpEF [Prospective Multicenter
This multicentre observational study highlighted the further prognostic importance of larger RVD among HFpEF patients with RV-PA uncoupling.
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