Tohoku University · Medicine
Professor Atsumu Kouketsu's research lab focuses on oral and maxillofacial oncology, with a strong emphasis on the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) and potentially malignant disorders. The lab investigates the role of human papillomavirus (HPV) infection, tumor microenvironment modulation by immune cells such as MDSCs and pDCs, and the immunosuppressive enzyme IDO1 in carcinogenesis and therapeutic response. Additionally, the lab explores regenerative strategies using biomaterials like OCP/Col for bone repair and contributes to the diagnosis and understanding of rare tumors such as mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) in the oral cavity.
Figures are computed from collected data and may differ slightly.
Objective Recent evidence suggests that human papillomavirus (HPV)‐related head and neck squamous cell carcinoma (HNSCC) is a separate HNSCC subgroup with distinct epidemiology, histopathological characteristics, therapeutic response to chemotherapy and radiation, and clinical outcome. This study aimed to investigate the role of HPV infection in oral squamous cell carcinoma (OSCC) and the correlation between HPV infection, tumor suppressor protein p16 expression, and clinicopathological features
The OCP/Col as a bone regeneration material not only exhibits osteoconductive activity that is dependent on residual healthy bone tissue, but also has osteoinductive capacity, which promotes angiogenesis and osteogenic cell invasion from host tissue into the bone defect.
Our proposed model is a potential diagnostic tool for oral diseases.
Myeloid-derived suppressor cells (MDSCs) help establish the tumor microenvironment by suppressing T-cell response in tumor-bearing hosts. Plasmacytoid dendritic cells (pDCs) activate antigen-specific T cells, thereby, maximizing their antitumor effects. IDO1 is associated with both MDSCs and pDCs and plays a major role in the formation of the tumor-mediated immunosuppressive environment. We utilized immunohistochemistry to examine the involvement of IDO1 in oral squamous cell carcinoma (OSCC) an
According to the authors' findings, fully erupted or superficially impacted mandibular third molars are a risk factor for angle fractures but at the same time a protective factor for the condyle. On the contrary, the absence of mandibular third molars "strengthens" the angle and represents a risk factor for condylar fractures.
Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare tumors recently characterized by the presence of both neuroendocrine and non-neuroendocrine components within the same tumor tissue. Although MiNEN found their place in the WHO classification for various organs, this composite tumor in the head and neck region remains exceptionally rare. We present a case of primary oral MiNEN in a 64-year-old male located on the left side of lower gingiva. Biopsy raised suspicion of neuroendocr
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