Tohoku University · Medicine
아츠시 마사무네 교수의 연구실은 췌장질환, 특히 췌장암과 만성 췌장염의 병태생리적 기전을 중심으로 연구를 진행하고 있습니다. 주로 췌장성 상피세포(pancreatic stellate cells, PSCs)의 활성화와 hypoxia 환경이 섬유화 및 염증 반응에 미치는 영향을 규명하고 있으며, 특히 피브리노겐이 PSCs의 섬유화 및 염증 반응을 유도하는 메커니즘을 밝혀내는 데 초점을 맞추고 있습니다. 또한 일본 내 자가면역성 췌장염(AIP)의 임상적 특성과 분류에 관한 데이터를 수집·분석하여 진단 및 치료 기반을 마련하고 있습니다.
Figures are computed from collected data and may differ slightly.
Pancreatic cancer is characterized by excessive desmoplastic reaction and by a hypoxic microenvironment within the solid tumor mass. Chronic pancreatitis is also characterized by fibrosis and hypoxia. Fibroblasts in the area of fibrosis in these pathological settings are now recognized as activated pancreatic stellate cells (PSCs). Recent studies have suggested that a hypoxic environment concomitantly exists not only in pancreatic cancer cells but also in surrounding PSCs. This study aimed to cl
UMIN000001818; Results.
The data represent the current clinical features of AIP in Japan.
The number of patients with AP is still increasing. The revised severity scoring system provided a more precise prediction of prognosis.
The data represent the current clinical features of AIP in Japan. From the results, most AIP patients in Japan can be categorized to type 1 AIP according to the recent classification of AIP.
Fibrinogen directly stimulated profibrogenic and proinflammatory functions in PSCs.
Activated pancreatic stellate cells (PSCs) have recently been implicated in the pathogenesis of pancreatic fibrosis and inflammation. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a ligand-activated transcription factor which controls growth, differentiation, and inflammation in different tissues. Roles of PPAR-gamma activation in PSCs are poorly characterized. Here we examined the effects of PPAR-gamma ligands on the key parameters of PSC activation. PSCs were isolated from r
Activated pancreatic stellate cells (PSCs) play an important role in pancreatic fibrosis and inflammation, where oxidative stress is implicated in the pathogenesis. NADPH oxidase might be a source of reactive oxygen species (ROS) in the injured pancreas. This study aimed to clarify the expression and regulation of cell functions by NADPH oxidase in PSCs. PSCs were isolated from rat and human pancreas tissues. Expression of NADPH oxidase was assessed by reverse transcription-PCR and immunostainin
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