The University of Tokyo · Medicine
Professor Ayumi Taguchi's research lab focuses on the molecular mechanisms underlying cervical carcinogenesis, with a particular emphasis on the tumor microenvironment, human papillomavirus (HPV)-associated pathogenesis, and the role of stromal cells such as cancer-associated fibroblasts (CAFs). The lab investigates how endogenous fatty acids, especially omega-3 polyunsaturated fatty acids, modulate tumor progression and angiogenesis, utilizing unique animal models like Fat-1 mice. They also employ advanced 3D organoid cultures to model the transformation zone of the uterine cervix, enabling studies on metaplasia, HPV infection, and disease progression. Additionally, the lab explores epigenetic and signaling pathways—such as SIRT1 and TRAIL—involved in endometriosis and cervical intraepithelial neoplasia (CIN) to identify potential therapeutic targets.
Figures are computed from collected data and may differ slightly.
Cancer associated fibroblasts (CAFs) are responsible for tumor growth, angiogenesis, invasion, and metastasis. Matrix metalloproteinase (MMP)-9 secreted from cancer stroma populated by CAFs is a prerequisite for cancer angiogenesis and metastasis. Omega-3 polyunsaturated fatty acids (omega-3 PUFA) have been reported to have anti-tumor effects on diverse types of malignancies. Fat-1 mice, which can convert omega-6 to omega-3 PUFA independent of diet, are useful to investigate the functions of end
These opposing effects of SIRT1-related agents suggest that IL-8 release from the ESC is modulated through the SIRT1 pathway. Resveratrol may have the potential to ameliorate local inflammation in endometriomas.
This study indicates that RVT suppresses survivin expression and enhances TRAIL-induced apoptosis in ESCs.
The metaplastic epithelium of the transformation zone (TZ) including the squamocolumnar junction (SCJ) of the uterine cervix is a prime target of human papilloma virus (HPV) infection and subsequent cancer development. Due to the lack of adequate in vitro models for SCJ, however, investigations into its physiological roles and vulnerability to carcinogenesis have been limited. By using Matrigel-based three-dimensional culture techniques, we propagated organoids derived from the normal SCJ region
Cervical intraepithelial neoplasia (CIN) has a natural history of bidirectional transition between different states. Therefore, conventional statistical models assuming a unidirectional disease progression may oversimplify CIN fate. We applied a continuous-time multistate Markov model to predict this CIN fate by addressing the probability of transitions between multiple states according to the genotypes of high-risk human papillomavirus (HPV). This retrospective cohort comprised 6022 observation
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