Seoul National University · Materials Science
Professor Chang Seok Ki's research lab specializes in biomaterials and tissue engineering, with a focus on developing advanced 3D cell culture systems using natural polymers such as silk fibroin and poly(ethylene glycol). The lab investigates the fabrication and characterization of nanofibrous scaffolds, hydrogels, and decellularized extracellular matrix (dECM) systems to mimic the complex tumor microenvironment and extracellular matrix for improved preclinical cancer modeling. Key research directions include dual-mode cross-linking strategies for tunable hydrogels, dynamic cell-matrix interactions in 3D, and the application of these platforms to study cancer cell behavior and drug responses. The lab aims to bridge the gap between traditional 2D cell culture and in vivo tumor physiology through biomimetic materials design.
Figures are computed from collected data and may differ slightly.
Abstract Practical application to three‐dimensional (3‐D) tissue culture has been limited by the structural restriction of two‐dimensional (2‐D) nature of electrospun nanofiber mat. In this study, for constructing 3‐D nanofibrous structure as real 3‐D tissue engineering scaffold, we developed new fabrication process with silk fibroin (SF) by electrospinning and evaluated the features of this SF nanofiber scaffold (SFNS) through morphological and cell‐culture analyses. Foam type of the SFNS exhib
Abstract Regenerated silk fibroin (SF) filaments could be prepared by wet spinning in common solvent/coagulation system. SF was directly dissolved in mixture solvent of phosphoric acid and formic acid (20/80–30/70 ratio) and coagulated in methanol bath. The concentration and stability of SF dope solution have been studied by varying the mixture ratios of these solvents in accordance with elucidating the role of formic acid in the mixture solvent system. Morphological structure as well as crystal
Hydrogel formation by more than two cross-linking mechanisms is preferred for the sophisticated manipulation of hydrogel properties. Both chemical and physical crosslinks are often utilized for fabricating stimuli-responsive hydrogels or for compensating the drawbacks of the single crosslinking method. In this study, silk fibroin (SF) microgel embedded poly(ethylene glycol) (PEG) hydrogels were fabricated by dual mode cross-linking based on thiol-ene photo-click chemistry and β-sheet formation o
Therapeutics to inhibit signaling of epidermal growth factor receptor (EGFR) has been suggested as a potential treatment for pancreatic cancers, and two-dimensional (2D) cell culture techniques are commonly used to identify and/or verify the therapeutic efficacy of EGFR inhibitors. However, drug targets identified from conventional cell culture techniques may not exhibit desired functions when these drugs are tested in animal studies, in large part due to the complicated tumor microenvironments.
Silk is a textile material, as well as one of the oldest biomaterials. However, the recent progress of biomedical science and technology has led to the replacement of silk by various biomaterials based on synthetic polymers. Despite the wide variety of biomaterials available, these materials suffer certain limitations that prevent them from meeting the various demands of the medical field. Therefore, silk continues to attract considerable interest as a promising biomaterial. This paper explains
Open papers in the app to read, cite, and organize with AI.
