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Changhoon Song

Seoul National University · Medicine

About the Lab

Professor Changhoon Song's research lab specializes in translational oncology and biomedical engineering, focusing on improving cancer treatment outcomes through innovative radiotherapy techniques and molecular biomarker discovery. The lab investigates neoadjuvant therapies, including chemoradiotherapy and single-fraction electron beam irradiation, for locally advanced or resistant cancers such as rectal, nasopharyngeal, and breast cancers. It also explores advanced energy storage systems, such as high-voltage supercapacitors with shape memory, for integration into implantable medical devices. The lab emphasizes personalized treatment strategies using molecular markers like HSP90, PI3K-p110α, and PTEN to predict disease relapse and guide therapy selection.

cancer radiotherapymolecular biomarkerssupercapacitorsneoadjuvant therapyprostate cancer

Research Overview

Papers
183
Total Citations
2,571
Papers (5y)
50
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
50total
2022
2023
2024
2025
2026
Citations per year (5y)
385total
20222023202420252026

Selected Papers

15
1
Article|82 citations·2010
Treatment-Related Pneumonitis and Acute Esophagitis in Non–Small-Cell Lung Cancer Patients Treated With Chemotherapy and Helical Tomotherapy
Changhoon Song, Hongryull Pyo, Sung Ho Moon, Tae Hyun Kim, Dae Woong Kim, Kwan Ho Cho
SJR Q1FWCI 5.5International Journal of Radiation Oncology*Biology*Physics
Pulmonary and Respiratory MedicineMedicine
2
Article|74 citations·2018
High performance wire-type supercapacitor with Ppy/CNT-ionic liquid/AuNP/carbon fiber electrode and ionic liquid based electrolyte
Changhoon Song, Junyeong Yun, Kayeon Keum, Yu Ra Jeong, Heun Park, Han-Chan Lee, Geumbee Lee, Seung Yun Oh, Jeong Sook Ha
SJR Q1FWCI 2.6Carbon
Electronic, Optical and Magnetic MaterialsMaterials Science
3
Article|73 citations·2018
Impact of Tumor Regression Grade as a Major Prognostic Factor in Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiotherapy: A Proposal for a Modified Staging System
Changhoon Song, Joo-Hyun Chung, Sung‐Bum Kang, Duck-Woo Kim, Heung‐Kwon Oh, Hye Seung Lee, Jin Won Kim, Jin Won Kim, Keun‐Wook Lee, Jee Hyun Kim, Jee Hyun Kim, Kim Js
SJR Q1FWCI 3.9CancersOA

There is ongoing debate regarding the significance of complete or near-complete response after neoadjuvant chemoradiotherapy (CRT) for rectal cancer. This study assessed the prognostic value of the Dworak tumor regression grade (TRG) following neoadjuvant CRT and surgery primarily in patients with pathological stage (ypStage) II and III rectal cancer. The records of 331 patients who underwent neoadjuvant CRT followed by total mesorectal excision between 2004 and 2015 were retrospectively reviewe

OncologyMedicine
4
Article|62 citations·2019
A Shape Memory High‐Voltage Supercapacitor with Asymmetric Organic Electrolytes for Driving an Integrated NO<sub>2</sub> Gas Sensor
Changhoon Song, Junyeong Yun, Han-Chan Lee, Heun Park, Yu Ra Jeong, Geumbee Lee, Min Su Kim, Jeong Sook Ha
SJR Q1FWCI 3.3Advanced Functional Materials

Abstract A high‐voltage supercapacitor with shape memory for driving an integrated NO 2 gas sensor is fabricated using a Norland Optical Adhesive 63 polymer substrate, which can recover the original shape after deformation by short‐time heating. The supercapacitor consists of multiwalled carbon nanotube electrodes and organic electrolyte. By using organic electrolyte consisting of adiponitrile, acetonitrile, and dimethyl carbonate in an optimized volume ratio of 1:1:1, a high operation voltage o

Biomedical EngineeringEngineering
5
Article|56 citations·2014
Adjuvant single-fraction radiotherapy is safe and effective for intractable keloids
Changhoon Song, H.G. Wu, Hak Chang, I. H. Kim, Sung Whan Ha
SJR Q2FWCI 2.8Journal of Radiation ResearchOA

The aim of this study was to assess the feasibility and efficacy of high-dose, single-fraction electron beam radiotherapy for therapy-resistant keloids. Before 2010, intractable keloids were treated at our institution with post-operative irradiation of 6-15 Gy in 3-5 fractionations. For convenience and cost effectiveness, we have changed our treatment protocol to high-dose single-fraction radiotherapy. A total of 12 patients with 16 keloid lesions were treated from January 2010 to January 2013 i

EpidemiologyMedicine
6
Article|51 citations·2010
Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers
Changhoon Song, So Yeon Park, Keun‐Yong Eom, Jee Hyun Kim, Sung‐Won Kim, Kim Js, In Ah Kim
SJR Q1FWCI 1.5Breast Cancer ResearchOA

The coexpression of HSP90 with PI3K-p110alpha or expression of HSP90 along with PTEN loss has a potential as a molecular prognostic marker to predict early relapse in patients with invasive breast cancers.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Article|50 citations·2008
Treatment Outcomes for Radiotherapy Alone are Comparable With Neoadjuvant Chemotherapy Followed by Radiotherapy in Early‐Stage Nasopharyngeal Carcinoma
Changhoon Song, Hong‐Gyun Wu, Dae Seog Heo, Kwang Hyun Kim, Myung‐Whun Sung, Charn Il Park
SJR Q1FWCI 2.9The Laryngoscope

Abstract Objectives: To analyze the impact of neoadjuvant chemotherapy (CT) on the treatment of early‐stage nasopharyngeal carcinoma (NPC) as compared with radiotherapy (RT) alone. Methods: We analyzed retrospectively the outcome of 60 previously untreated and histologically confirmed early‐stage NPC patients treated with either RT alone or with neoadjuvant CT followed by RT (CT/RT) at the Seoul National University Hospital between 1986 and 2004. Neoadjuvant CT consisted of three cycles with 5‐f

OtorhinolaryngologyMedicine
8
Article|32 citations·2016
Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization
Changhoon Song, Beom-Ju Hong, Seoyeon Bok, Chan-Ju Lee, Young-Eun Kim, Sang-Rok Jeon, Hong‐Gyun Wu, Yun‐Sang Lee, Gi Jeong Cheon, Jin Chul Paeng, David J. Carlson, Hak Jae Kim
SJR Q1FWCI 1.7International Journal of Radiation Oncology*Biology*Physics
Cancer ResearchBiochemistry, Genetics and Molecular Biology
9
Article|17 citations·2015
Elective pelvic versus prostate bed-only salvage radiotherapy following radical prostatectomy
Changhoon Song, Hyun‐Cheol Kang, Kim Js, Keun‐Yong Eom, In Ah Kim, Jin‐Beom Chung, Sung Kyu Hong, Seok‐Soo Byun, Sang Eun Lee
SJR Q2FWCI 2.4Strahlentherapie und Onkologie
Pulmonary and Respiratory MedicineMedicine
10
Article|12 citations·2019
Elective pelvic irradiation in prostate cancer patients with biochemical failure following radical prostatectomy: A propensity score matching analysis
Changhoon Song, Sang Jun Byun, Young Seok Kim, Hanjong Ahn, Seok‐Soo Byun, Choung‐Soo Kim, Sang Eun Lee, Kim Js
SJR Q1FWCI 1.4PLoS ONEOA

These data suggest that, following radical prostatectomy, elective WPRT during SRT may improve bRFS compared with PBRT in selected patients. Patients with preoperative PSA level ≤20 ng/mL or pre-SRT PSA level ≥0.4 ng/mL represent a potential subgroup who benefit most from receiving WPRT. Results of prospective randomized trials are awaited to confirm this finding.

Pulmonary and Respiratory MedicineMedicine
11
Article|11 citations·2013
Nomogram Prediction of Survival and Recurrence in Patients With Extrahepatic Bile Duct Cancer Undergoing Curative Resection Followed by Adjuvant Chemoradiation Therapy
Changhoon Song, Kyubo Kim, Eui Kyu Chie, Jin Ho Kim, Jin‐Young Jang, Sun‐Whe Kim, Sae‐Won Han, Do‐Youn Oh, Seock‐Ah Im, Tae‐You Kim, Yung‐Jue Bang, Sung Whan Ha
SJR Q1FWCI 0.9International Journal of Radiation Oncology*Biology*Physics
SurgeryMedicine
12
Article|11 citations·2009
Experimental Study on Soot Oxidation Characterization of Pt/CeO&lt;sub&gt;2&lt;/sub&gt; Catalyst with NO and O&lt;sub&gt;2&lt;/sub&gt; Using a Flow Reactor System
Changhoon Song, Jin‐Woo Jung, Soonho Song, Kwang Min Chun
FWCI 0.5SAE technical papers on CD-ROM/SAE technical paper series

&lt;div class="htmlview paragraph"&gt;The oxidation of soot (carbon black) which is assisted by Pt/CeO&lt;sub&gt;2&lt;/sub&gt; catalyst is studied using a flow reactor system simulating the condition of diesel exhaust. In this study, the temperature programmed oxidation (TPO) scheme is mainly used for different NO and O&lt;sub&gt;2&lt;/sub&gt; concentrations and soot oxidation rate is evaluated by monitoring both CO and CO&lt;sub&gt;2&lt;/sub&gt; concentrations.&lt;/div&gt; &lt;div class="htmlvi

Materials ChemistryMaterials Science
13
Article|10 citations·2022
Survival impact of prophylactic cranial irradiation in small-cell lung cancer in the modern era of magnetic resonance imaging staging
Yu Jin Lim, Changhoon Song, Hak Jae Kim, Korea Central Cancer Registry
SJR Q1FWCI 0.9Radiation OncologyOA

In the modern era of MRI staging, PCI might be beneficial for patients with limited-stage SCLC but not for those with extensive-stage SCLC. Further studies with a large sample size are needed to verify the prognostic association of PCI.

OncologyMedicine
14
Preprint|9 citations·2022
Minimal Width for Universal Property of Deep RNN
Changhoon Song, Geonho Hwang, Jun ho Lee, Myungjoo Kang
arXiv (Cornell University)OA

A recurrent neural network (RNN) is a widely used deep-learning network for dealing with sequential data. Imitating a dynamical system, an infinite-width RNN can approximate any open dynamical system in a compact domain. In general, deep networks with bounded widths are more effective than wide networks in practice; however, the universal approximation theorem for deep narrow structures has yet to be extensively studied. In this study, we prove the universality of deep narrow RNNs and show that

Artificial IntelligenceComputer Science
15
Article|9 citations·2022
Accurate Non-Contact Body Temperature Measurement with Thermal Camera under Varying Environment Conditions
Changhoon Song, Sukhan Lee
FWCI 2.02022 16th International Conference on Ubiquitous Information Management and Communication (IMCOM)

Non-contact measurement of body temperature is preferred due not only to the convenience it provides but also to the necessity for preventing medical staffs and patients from infection and safety risk. For non-contact body temperature measurement, thermal cameras have been used to measure the temperature of facial skins. However, the problem is that temperature of facial skins varies according to varying environmental conditions such as outside temperature, subject activities prior to measuremen

Radiology, Nuclear Medicine and ImagingMedicine

Research Areas

OncologyPulmonary and Respiratory MedicineRadiationSurgeryBiomedical EngineeringRadiology, Nuclear Medicine and Imaging

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