Waseda University · Medicine
Professor Chien-Yu Lin's research lab focuses on molecular and translational neuroscience, particularly investigating the roles of sialyltransferases—such as ST8SIA2 and ST8SIA3—in brain glycosylation and their implications in neuropsychiatric disorders like schizophrenia. The lab also explores the physiological and pathological functions of glycoconjugates in the central nervous system, with a focus on G-protein-coupled receptors in brain regions like the striatum. In addition, the lab engages in biomedical engineering research, including the development of high-efficiency power electronics systems using wide-bandgap semiconductors like gallium nitride for energy conversion applications. The integration of molecular biology, neuroscience, and power electronics reflects the lab’s interdisciplinary approach to understanding biological mechanisms and advancing health-related technologies.
Figures are computed from collected data and may differ slightly.
The protocol of this systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) on 2 December 2019 (registration number: CRD42019137341 ).
Sialic acids are typically added to the end of glycoconjugates by sialyltransferases. Among the six ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferases (ST8SIA) existing in adult brains, ST8SIA2 is a schizophrenia-associated gene. However, the in vivo substrates and physiological functions of most sialyltransferases are currently unknown. The ST8SIA3 is enriched in the striatum. Here, we showed that ablation of St8sia3 in mice (St8sia3-KO) led to fewer disialylated and trisialylated terminal gly
The findings have implications for allocating prevention and intervention resources targeted at high-risk groups in high incidence areas. Targets for area-based interventions might include tackling the causes and consequences of joblessness, better treatment of long-term illness and consideration of the accessibility of health services.
In this study, a buck power factor corrector (PFC) with gallium nitride field effect transistor (GaN FET) and integrated inductor is studied. An interleaved constant‐frequency clamped‐current control method is adopted to achieve high power factor, low input and output current ripples as well as high efficiency. Two inductors in the studied interleaved buck PFC are integrated to reduce the core loss. A 300 W/80 V laboratory prototype with 300 kHz switching frequency was built and tested under uni
Suicide rates and the prevalence of suicidal behaviors began to increase in Taiwanese youth in the 2010s. These increases may be associated with concurrent rises in parental divorce rates, Internet use and poor sleep. Further research is needed to examine the mechanisms underlying recent increases in youth suicide risk.
The study aimed to describe the prevalence of meeting moderate-to-vigorous-intensity physical activity (MVPA), muscle-strengthening (MS) activities, and television (TV) viewing guidelines, and their association with sociodemographic factors. Data from older adults aged 65 or above were sampled by age and sex to the population aged 65+ years for each area in Taiwan and collected through telephone interviews. The prevalence of meeting MVPA and MS activities, MVPA and MS activities guidelines, and
<b></b> <i>Background:</i> Few studies have investigated whether means accessibility is related to the spatial distribution of suicide. <i>Aims:</i> To examine the hypothesis that indicators of the accessibility to specific suicide methods were associated with method-specific suicide rates in Taipei City, Taiwan. <i>Method:</i> Smoothed standardized mortality ratios for method-specific suicide rates across 432 neighborhoods and their associations with means accessibility indicators were estimate
The investigated perceived environmental factors, which have previously been associated with facilitating active transportation, discourage sedentary modes of transport, such as motorized vehicles.
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