Seoul National University · Medicine
Professor Chong-Su Kim's research lab specializes in gut-brain axis mechanisms, focusing on how gut microbiota and their metabolites influence brain function and mental health in aging and psychological stress. The lab investigates the roles of probiotics, dietary fiber, and microbial metabolites—particularly indole-3-propionic acid (IPA)—in modulating neuroinflammation, cognition, and mood disorders such as depression and anxiety. Using integrative approaches including 16S rRNA sequencing, clinical trials, and systems biology, the lab aims to identify microbiome-based interventions for promoting brain health in older adults and vulnerable populations. Their work bridges microbiology, neuroscience, and nutrition science to develop evidence-based strategies for mental well-being.
Figures are computed from collected data and may differ slightly.
Probiotics have been proposed to ameliorate cognitive impairment and depressive disorder via the gut-brain axis in patients and experimental animal models. However, the beneficial role of probiotics in brain functions of healthy older adults remains unclear. Therefore, a randomized, double-blind, and placebo-controlled multicenter trial was conducted to determine the effects of probiotics on cognition and mood in community-dwelling older adults. Sixty-three healthy elders (≥65 years) consumed ei
These results show that gut microbiota-produced IPA plays a role in protecting the microglia from inflammation, thus promoting neuronal function. Therefore, this suggests that IPA is a significant mediator linking the interaction between the gut and the brain in the elderly with probiotic supplementation.
Gut microbiota have crucial effects on brain function via the gut-brain axis. Growing evidence suggests that this interaction is mediated by signaling molecules derived from dietary components metabolized by the intestinal microbiota. Although recent studies have provided a substantial understanding of the cell-specific effects of gut microbial molecules in gut microbiome-brain research, further validation is needed. This review presents recent findings on gut microbiota-derived dietary metaboli
These results suggest that probiotic food consumption might have beneficial effects on depression, particularly in men. Further studies are required to identify the mechanistic relations between probiotics and depression.
Gut microbiota is suggested to regulate the host's mental health via the gut-brain axis. In this study, we investigated the relationship between the microbiome and psychological pain due to social exclusion. Adult individuals with (n = 14) and without (n = 25) social exclusion experience were assessed for the psychological status using self-reported questionnaires: Beck Anxiety Inventory (BAI), Beck Depression Inventory, and the UCLA Loneliness Scale. The gut microbiota was analyzed by 16 S rRNA
Dietary fiber has been actively studied for its profound impacts on mental health by affecting the gut-brain axis communication. However, the association between dietary fiber intake and depression has been inconsistent, partly due to the lack of consideration of the fiber source. Therefore, this study aimed to examine the association between various sources of dietary fiber and depression in Korean adults through a nationwide cross-sectional study. The study population was a total of 2960 adult
These results suggest that probiotic supplementation may reduce the incidence of inflammation-related diseases by regulating the profiles of the gut microbiota and peripheral immune cells in healthy elders in a sex-specific manner.
Infancy and childhood are periods of physical and cognitive development that are vulnerable to disruption by dehydration; however, the effects of dehydration on cognitive development during the periods have not yet been fully elucidated. Thus, the present study used a murine model to examine the effects of sustained dehydration on physical growth and cognitive development. Three-week-old C57BL/6J mice were provided either ad libitum (control group) or time-limited (15 min/day; dehydration group)
「고려사(高麗史)」 「악지(樂志)」에서는 음악의 계통에 따라 분류하여 속악(俗樂)을 연주하는 악기와 당악(唐樂)을 연주하는 악기로 나누고, 「악학궤범(樂學軌範)」에서는 악기의 연원에 따라 분류하여 중국을 통해 들어왔다고 간주되는 악기를 당악기, 오래 전부터 우리나라에서 연주되어왔다고 간주되는 악기를 향악기로 나누어, 악기분류 방식이 서로 다르다. 「고려사」와 「악학궤범」이 편찬된 조선전기에 속악은 당악과 대비되어 향악을 뜻하기도 하고, 아(雅樂)과 대비되어 향악⋅당악⋅신악(新樂)을 뜻하기도 하였다. 「고려사」 「악지」의 악기분류에 쓰인 속악은 향악을 뜻하는 용어로 쓰인 것이다. 고려시대에는 송(宋)에서 많은 당악이 들어와 고려사회에 풍미했다. 이 당시는 당악곡이 중국식으로 연주되어, 향악을 연주하는 악기와 당악을 연주하는 악기가 확연히 구분되었다. 즉, 박(拍)이나 장고와 같은 타악기를 제외한 관현악기의 경우, 당악기로 당악만을 연주하고, 향악기로는 향악만을 연주하였다. 그러나
수보록(受寶)ㆍ몽금척(夢金尺)은 태조(太祖: 1335~1408, 재위: 1392∼1398)의 치적을 찬양하기 위해 1393년(태조 2) 7월에 정도전(鄭道傳, 1342~ 1398)이 지어 올린 악장(樂章)이고, 근천정(覲天庭)수명명(受明命)은 태종(太宗: 1367~1422, 재위: 1400∼1418)의 치적을 찬양하기 위해 1402년(태종 2) 6월에 하륜(河崙, 1347~1416)이 지어 올린 악장이다. 임금에게 악장을 올리자마자, 곧 악공(樂工)으로 하여금 연습하게 하고 연향악으로 삼도록 명하였다. 이는 기존 악곡의 선율에 얹혀져 악장이 노래 불리웠음을 암시해준다. 수보록(受寶)몽금척(夢金尺)근천정(覲天庭)수명명(受明命)은 악장이 지어지자, 기존 당악(唐樂) 선율에 맞추어 노래 부르고 춤추는 당악정재(唐樂呈才) 양식으로 연행되었다.그런데 세종(世宗: 1397∼1450, 재위: 1418∼1450) 중기에 아악정비가 일단락된 이후는 수보록(受寶)근천정(覲天庭)수명명(受明命)이 아악곡
The intricate relationship between nutrition, gut microbiome, and mental health has gained increasing attention. We aimed to determine how vitamin C supplementation improves mental vitality through the gut microbiome and associated neurological and immunological changes. We used 16S rRNA sequencing to analyze gut microbiota profiles of participants from our previous trial, in which healthy young adults (20-39 years) with inadequate serum vitamin C levels (< 50 μM) received 500 mg vitamin C or a
조선 초기에 대비와 중궁 및 명부(命婦) 등이 참석하는 내연(內宴)이나 임금과 신하가 참석하는 외연(外宴)을 막론하고, 춤과 노래는 모두 여악이 담당했다. 그런데 여악으로 인한 풍기문란 등의 문제가 종종 발생하므로, 치인(治人)의 위치에 있는 위정자(爲政者)가 모범을 보이기 위해, 군신(君臣) 간의 예연(禮宴)에서는 종래 여악이 해오던 춤과 노래를 남자아이로 대체하기로 하고, 1431년(세종 13) 8월에 이들이 입을 관복에 대해 논의하는데, 이때 무동이란 호칭이 처음 등장했다. 1432년(세종 14)에 공천(公賤) 중에서 10세가량의 어린 소년 60명을 뽑아 1433년(세종 15) 정월 회례연에서 공연한 것이 조선시대 무동제도의 시작이다. 무동은 <몽금척>⋅<오양선>⋅<아박>⋅<무고> 등의 정재를 공연했는데, 이들 정재는 노래와 춤으로 구성되어 있으므로, 무동은 노래하고 춤추는 소년을 뜻한다. 무동은 성인 남자의 체격과 목소리를 갖추기 전까지만 활동했으므로 대략 활동 상한선이 15
Altogether, we demonstrate transcriptional events during renal development in infancy and show that the impacts of inadequate water intake in the early postnatal state heavily rely on the impairment of normal renal development. Here, we provide a meaningful perspective of renal development in infancy with a molecular and physiological explanation of why infants are more vulnerable to dehydration than adults. These results provide new insights into the molecular effects of dehydration on renal ph
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