Chulho Sohn
Seoul National University · Medicine
About the Lab
Professor Chulho Sohn's research lab specializes in advanced neuroimaging techniques, particularly focusing on the application of 3T MRI and perfusion imaging in acute cerebrovascular diseases. The lab investigates the diagnostic utility of sequences such as GRE T2*-weighted, FLAIR, DWI, and ASL in conditions like subarachnoid hemorrhage, brain death, and acute ischemic stroke. A key research direction involves understanding hemodynamic changes and perfusion abnormalities, especially the impact of delayed cerebral blood flow on quantitative imaging metrics like CBF in arterial occlusion. The lab also explores the pathophysiological mechanisms underlying early brain injury and stroke outcomes through multimodal MRI.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Cavernous hemangiomas occur very rarely in the cavernous sinus and are difficult to diagnose preoperatively. MR images obtained in five patients with surgically verified cavernous hemangiomas in the cavernous sinus were reviewed. MR images showed hypointensity on T1-weighted images and well-defined hyperintensity on T2-weighted images with marked homogeneous enhancement after contrast material administration. We report the characteristic MR imaging observations for these lesions.
We describe MR imaging findings applying gradient echo (GRE) T2*-weighted and fluid-attenuated inversion recovery (FLAIR) MR images at 3T to three patients with hyperacute subarachnoid and intraventricular hemorrhage from ruptured aneurysms. Hyperacute subarachnoid and intraventricular hemorrhages (SAH and IVH) were more clearly visualized as an area of decreased signal intensity on GRE T2*-weighted sequences than on FLAIR sequences in all three patients. These preliminary results suggest that a
T2-weighted imaging, DWI, and MRA using 3T MRI may be useful for diagnosing brain death. However, SWI findings are not specific due to high false positive findings.
Stroke mechanism has a major influence on outcomes, and outcome predictors differ according to the underlying mechanism in acute BA occlusion with EVT. Clot sign profile on pre-angiography MRI might be useful to determine the underlying mechanism.
Our results demonstrate that the correlation between the CBF values from the ASL and DSC tends to be weaker when the transit time is more delayed, with the restoration of the strength of the correlation when the TTP is extremely delayed (>25 seconds). Understanding the effect of delayed transit time on the CBF from ASL perfusion MR in a clinical setting would facilitate the proper interpretation of ASL images.
ASL imaging could detect CCD in 75% of patients with hyperacute infarction. We found that CCD was more prevalent in patients with arterial occlusion, larger ischemic brain volumes, and higher initial NIHSS and mRS scores. In particular, vessel occlusion and initial mRS score appeared to be significantly related with CCD pathophysiology in the hyperacute stage.
Serial administrations of gadobutrol did not result in signal increases in the DN or GP on unenhanced T1-weighted MR images due to gadolinium retention.
Neither carotid nor intracranial artery stenosis appears to be associated with brain Aβ burden, while intracranial artery stenosis is related to amyloid-independent neurodegeneration, particularly hippocampal atrophy.
Mean transit time is the most predictive parameter for assessing decreased CVR in patients with unilateral steno-occlusive vascular disease.
Relative hippocampal volume measures provided by automated brain segmentation software can be useful for screening cerebral Aβ positivity in clinical practice for patients with amnestic MCI. The information may also help clinicians interpret structural MRI to predict outcomes and determine early intervention for delaying the progression to Alzheimer's disease dementia.
Intravenous iron treatment results in changes in brain iron content which correlate to reductions in RLS severity. This suggests a connection between symptom improvement and the associated specific brain regions constituting the sensorimotor network.
Herein, we report on an unusual case of craniopharyngioma arising in the temporal lobe with no prior history of surgery and with no connection to the craniopharyngeal duct. MR images showed a cystic tumor with a small solid portion. To the best of our knowledge, this is the first case of a craniopharyngioma occurring in the temporal lobe.
The preoperative examinations by doppler-sonography of 83 patients with tumors of the breast are presented. The examinations are done with newest technique: duplex-sonography in slow-flow-technique (AI 3200, Dornier); colour-sonography in MEM-technique (AI 5200, Dornier) and synchronical colour-doppler++ (Quantum 2000, Siemens) and CW-doppler-sonography (Vasocope 3, Kranzbühler). There is a markable difference between the side of carcinoma and the normal side as well as pre- and postmenopausal p
Research Areas
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