Dahyun Yi

Despite potential implications for the early detection of impending Alzheimer's disease (AD), very little is known about the differences of large-scale brain networks between amnestic mild cognitive impairment (aMCI) with high cerebral amyloid-beta protein (Aβ) deposition (i.e., aMCI+) and aMCI with no or very little Aβ deposition (i.e., aMCI-). We first aimed to extend the current literature on altering intrinsic functional connectivity (FC) of the default mode network (DMN) and salience networ

Recently, the field of gene-gene or gene-environment interaction research appears to have gained growing interest, although it is seldom investigated in Alzheimer’s disease (AD). Hence, the current study aims to investigate interaction effects of the key genetic and environmental risks—the apolipoprotein ε4 allele (APOE4) and family history of late-onset AD (FH)—on AD-related brain changes in cognitively normal (CN) middle-aged and older adults. [11C] Pittsburg compound-B (PiB) positron emission

With the rapid digital transformation of many industries and the world of work, the legal status of digital platform workers, a new type of service provider who works through digital platforms and earns income, is being continuously questioned. Recently, the Korean Supreme Court has ruled that on-demand delivery worker via digital app is entitled to compensation under Korean Industrial Accident Compensation Act, but courts are still slow in protecting them as employees under the Labor Standard A

Angiogenesis must be precisely controlled because uncontrolled angiogenesis is involved in aggravation of disease symptoms. Vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR-2) signaling is a key pathway leading to angiogenic responses in vascular endothelial cells (ECs). Therefore, targeting VEGF/VEGFR-2 signaling may be effective at modulating angiogenesis to alleviate various disease symptoms. Oleanolic acid was verified as a VEGFR-2 binding chemical from anticancer herbs with

We aimed to develop a word-reading test for Korean-speaking adults using irregularly pronounced words that would be useful for estimation of premorbid intelligence. A linguist who specialized in Korean phonology selected 94 words that have irregular relationship between orthography and phonology. Sixty cognitively normal elderly (CN) and 31 patients with Alzheimer's disease (AD) were asked to read out loud the words and were administered the Wechsler Adult Intelligence Scale, 4th edition, Korean

Tau burden in the LC was significantly associated with cortical tau accumulation. Tau burden in SN or PPN showed no association with cortical tau accumulation. LC tau burden was serially associated with Braak stages. The tau-LC and cortical tau relationship was significant only in the Aβ-positive group. Cortical amyloid's impact on memory worsens with higher tau accumulation in the LC.

기본소득(basic income)은 국가가 자산심사와 근로 요구 없이 모든 개인에게 주기적이고 무조건적으로 지급하는 현금을 의미하며, 보편성, 무조건성, 개별성, 정기성 등을 그 개념 요소로 한다. 글로벌 경제의 불평등과 함께 우리나라에서도 사회경제적 양극화 현상이 심화되는 추세이며, 최근 4차 산업혁명 담론과 함께 디지털 기술혁신으로 인한 고용 감소에 대한 우려가 확산되는 상황 속에서 기본소득은 경제적 부정의를 해소하는 데 기여할 수 있는 대안적 제도로 주목받고 있어 법적 검토의 필요성이 크다. 기본소득에 대한 기존의 논의들은 기본소득과 노동의 관계에 대해 다소 모호하거나 부정적인 입장을 취하는 경우가 많았다. 기본소득이 근로 여부와 무관하게 주어지는 소득이라는 점을 주로 강조하여 기본소득을 시행할 경우 노동의 사회적 가치가 평가절하되거나, 기존 노동법 체계와의 정합성을 우려하는 입장들이 존재한다. 그러나 본 논문에서는 기본소득과 노동이 상호 배치되는 것이 아니라 상호 보완적으로

Abstract Background KBASE is a prospective cohort study launched at Seoul National University (SNU), South Korea, in 2014 using similar design and methods as the North American Alzheimer’s Disease Neuroimaging Initiative (ADNI). The KBASE cohort consists of well‐characterized participants (420 cognitively normal, 140 mild cognitive impairment, and 90 AD dementia) ( Figure 1 ). It includes systematic longitudinal collection of comprehensive clinical, cognitive and lifestyle data, multimodal neuro

20세기 초 미국의 ‘노동가처분(labor injunction)’은 노동운동을 저지하기 위하여 활용되던 법원의 관행이었다. 당시 일반대중인 노동자들의 지위는 매우 열악하였으므로 노동분쟁이 빈번히 발생하였으나, 보수적인 성향의 판사들은 현실을 외면하고 노동조합의 활동을 즉각 중단시키는 가처분을 남발하곤 하였다. 노동가처분이 인정된 주요 판결들에서는 파업이나 피켓팅으로 인하여 사용자의 재산권이 조금이라도 침해될 여지가 보이면 커먼로의 형평법 원칙을 적용하여 노동자측에 사전통지나 심리 기회 없이 해당 행위에 대한 가처분을 발하였다. 사법부가 노동자들을 탄압하는 이러한 폐단은 결국 일련의 입법과정을 통해 점진적으로 사라지게 되었다. 근로자의 단결을 경제적 담합으로 해석하지 못하도록 한 클레이턴법(1914), 가처분의 관할권을 제한한 노리스-라가디아법(1932), 뉴딜정책의 일환인 연방노동관계법(1935) 등이 그것이다. 오늘날 미국에서는 과거와 같이 사용자에게만 일방적으로 유리한 노동가처분

Gene-based analysis identified CLU and FYN as associated with tau deposition on positron emission tomography (PET). CLU rs149413552 and FYN rs57650567 were associated with brain tau deposition. rs149413552 and rs57650567 were associated with structural brain atrophy. CLU rs149413552 was associated with immediate verbal memory. CLU and FYN may play specific roles in tau pathophysiology.

Evaluating illiterate women using existing standards has the limitation of underestimating their performance relative to their actual skills. The present normative data are expected to enable researchers and clinicians to more accurately evaluate the results of the three verbal episodic memory tests, including the Word List Memory, Word List Recall, and Word List Recognition in older illiterate Korean women.

As part of social distancing since Covid-19, telework has rapidly spread, and its importance is being highlighted. In Korea, the utilization of teleworkers is increasing, and the Ministry of Employment and Labor's guidelines and manuals for introducing telework have been announced. However, telework is not yet regulated by Korean Employment Standard Act, so legal review is needed to establish basic principles and protect workers. International standards for telecommuting include the C177 Home Wo

Abstract Background We first aimed to investigate the association between regional white matter (WM) microstructural alterations with tau deposition in Alzheimer’s disease (AD) signature cortical regions. We also tried to develop models to predict pathological tau deposition positivity with regional WM microstructural alterations. Method One‐hundred nine older adults with normal cognition or mild cognitive impairment recruited from the Korean Brain Aging Study for the Early diagnosis and predict