Sungkyunkwan University · Medicine
Professor Deok Hyun Han's research lab specializes in urological interventions and molecular urology, focusing on minimally invasive treatments for nephrolithiasis and the underlying cellular mechanisms of male hormone action in vascular function. The lab investigates advanced endourological techniques such as retrograde intrarenal surgery (RIRS) with high-power laser lithotripsy, as well as the role of ion channels in urological and vascular pathophysiology. Their work bridges clinical outcomes with molecular signaling, particularly testosterone’s modulation of potassium channels and calcium homeostasis in smooth muscle. The lab also explores palliative therapies for malignant urological obstructions, emphasizing safety and efficacy in real-world clinical settings.
Figures are computed from collected data and may differ slightly.
There was a gradual but constant change in treatment trends of nephrolithiasis, with an increasing trend for RIRS and a decreasing trend for SWL. Although PCNL has relatively invasive characteristics, it is still in steady demand.
The results of patch-clamp studies provided direct molecular evidence that testosterone stimulates the activity of BK(Ca) channels and K(ATP) channels. An understanding of the signaling mechanisms that couple testosterone receptor activation to potassium channel stimulation will provide us with an insight into the cellular processes underlying the vasorelaxant effects of testosterone.
These data show that Uventa can be an effective and safe option for palliative treatment of patients with MUO in a large series of patients.
• SCE induced relaxation of CSM that occurred primarily via an endothelium-independent pathway. • The relaxation effects of SCE on CSM were, in part, due to the activation of K(+) channels and inhibition of TRPC6 channels, resulting in decreased [Ca(2+)](i).
<b><i>Objective:</i></b> Recently, retrograde intrarenal surgery (RIRS) using laser lithotripsy has become popular. However, the optimal laser energy setting for pop-dusting has not been established. In this study, we report our experiences of RIRS using the high-power (up to 100 W) pop-dusting (HPPD) technique. <b><i>Methods:</i></b> This study retrospectively assessed 82 cases with RIRS using HPPD. Patients who underwent abdominal CT or mercaptoacetyltriglycine (MAG3) diuretic renal scan at 3
Ultrasound estimated bladder weight/corrected ultrasound estimated bladder weight is a statistically significant parameter correlating with bladder outlet obstruction. However, bladder weight/corrected bladder weight alone was insufficient to predict bladder outlet obstruction due to its weak correlation with and low accuracy for diagnosing obstruction.
Encrustation and/or biofilm formation in ureteral stents are major causes of obstruction and reduce the lifetime of a ureteral stent. In this study, the inner surfaces of polyurethane (PU) tubes (inner and outer diameters of 1.2 and 2.0 mm, respectively) were reformed with Ar, O<sub>2</sub>, and C<sub>2</sub>H<sub>2</sub> gases using specialized plasma-enhanced chemical vapor deposition techniques for the first time. Then, the modified PU tubes were immersed in urine for 15 days, and the charact
During the last 2 decades, the role of retrograde intrarenal surgery (RIRS) has markedly expanded as an advanced treatment modality for urinary calculi. RIRS is now considered as a first-line treatment of renal stones sized less than 20 mm regardless of stone location, stone composition, or renal anatomy because of high success rates and low morbidities [1,2]. The stone-breaking and retrieval method is one of the most interesting aspects of RIRS. Traditionally, stone retrieval with a basket a
PVP could reduce the prostate volume effectively and relieve bladder outlet obstruction similar to TURP by the 6-month follow up in men with BPH.
Purpose: Erectile dysfunction(ED) impacts the quality of a man's life, both from a social and humanistic perspective. This study was performed to determine the themes, coping behaviors, and influencing factors related to men's health, with a special focus on ED, in Korean males. Materials and Methods: Subjects for this study included 32 ED men and 32 non-ED men. A total of 8 focus group discussions were conducted for each group, separately. Inclusion into the ED group was confirmed by IIEF-5 sc
LESS-NL is a safe, feasible, and definitive treatment option for symptomatic caliceal diverticular calculi.
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