Seoul National University · Biochemistry, Genetics and Molecular Biology
Professor Doman Kim's research lab specializes in bioactive compound discovery and functional food development, focusing on natural products from plants and microorganisms. The lab investigates the enhancement of bioavailability and stability of bioactive molecules—such as curcuminoids and phenolic compounds—through novel extraction and solubilization techniques. It also explores microbial fermentation processes to enrich functional nutrients like GABA, L-carnitine, and phenolic acids in plant-based foods. Additionally, the lab engages in molecular enzymology, particularly the cloning and characterization of novel enzymes like glucansucrases from lactic acid bacteria.
Figures are computed from collected data and may differ slightly.
Curcuminoids from rhizomes of Curcuma longa possess various biological activities. However, low aqueous solubility and consequent poor bioavailability of curcuminoids are major limitations to their use. In this study, curcuminoids extracted from turmeric powder using stevioside (Ste), rebaudioside A (RebA), or steviol glucosides (SG) were solubilized in water. The optimum extraction condition by Ste, RebA, or SG resulted in 11.3, 9.7, or 6.7mg/ml water soluble curcuminoids. Curcuminoids solubili
Weissella cibaria isolated from human saliva produces a soluble glucan that predominantly has alpha-1,6-glucosidic type linkages. Using degenerated primers that were selected based on the amino acid sequences of conserved regions from known glucansucrases, a single 2.7-kb fragment was isolated. In subsequent steps, a 4969-bp product was obtained using inverse PCR. The coding region for the glucansucrase gene (dsrWC) consisted of a 4419-bp ORF that encoded a 1472-amino acid protein with a calcula
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