Sungkyunkwan University · Medicine
Professor Dong Il Park's research lab specializes in gastrointestinal oncology and digestive disease, with a strong focus on non-invasive colorectal cancer screening, endoscopic management of early neoplasia, and the pathophysiology of gastroesophageal reflux disease (GERD). The lab investigates epigenetic biomarkers—such as promoter hypermethylation of MGMT, hMLH1, and vimentin—in stool samples to improve early detection of colorectal cancer. It also explores innovative endoscopic techniques like qFIT and prepackaged low-residue diets to enhance patient compliance and diagnostic accuracy.
Figures are computed from collected data and may differ slightly.
The qFIT provides a higher sensitivity for detecting ACRN and cancer than the GT, and has an acceptable specificity that significantly reduces the need for colonoscopic evaluation in the screened population.
CT-P13 appears to have comparable efficacy, safety, and interchangeability with its originator in the treatment of IBD. Further prospective studies with long-term follow-up periods will be needed to confirm the biosimilarity of CT-P13.
These results suggest that a diagnosis of high-grade dysplasia in forceps biopsy material should be considered an absolute indication for ESP or EMR.
Abstract Background: The relationship between obesity and gastroesophageal reflux disease (GERD) is controversial. The aim of the present study was to investigate the potential roles of body mass index (BMI) and waist circumference on GERD in a Korean population. Methods: A total of 2457 subjects who visited the Kangbuk Samsung Hospital medical screening center for esophagogastroduodenoscopy from September 2004 to April 2005 were enrolled. All participants were given a questionnaire to determine
Our results have demonstrated that the promoter hypermethylation for methylguanine DNA methyltransferase, human Mut L homolog-1, and vimentin in stool samples is a feasible epigenetic marker that is a sensitive, specific, and noninvasive alternative for colorectal cancer screening. This method of screening for colorectal cancer may be useful for patients that decline screening because of fear or inconvenience.
A prepackaged low residue one-day diet provided cleansing efficacy similar to that of a clear liquid diet and offered the benefit of improved tolerability compared to the conventional PEG 4L regimen.
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