Yonsei University · Medicine
Professor Eui Hyun Kim's research lab specializes in neurosurgical oncology and endocrine neurosurgery, with a focus on improving outcomes in brain tumors and pituitary disorders. The lab investigates novel therapeutic strategies for glioblastoma by targeting cancer stem cells through metabolic inhibition, as well as exploring predictive biomarkers—such as radiomic features and hormonal responses—for personalized treatment in prolactinomas and acromegaly. The team also contributes to the understanding and diagnosis of rare neurological conditions, including IgG4-related hypertrophic pachymeningitis, emphasizing the importance of histopathological and imaging-based differentiation. Their work bridges clinical neurosurgery with translational research, aiming to enhance surgical outcomes and guide adjuvant therapies.
Figures are computed from collected data and may differ slightly.
Immediate postoperative GH level is a very good predictor of long-term outcome in acromegaly. One-week postoperative OGTT is also a good predictor with high specificity. These findings may provide critical information for the determination of adjuvant treatment after surgery.
The combination of 2DG and metformin effectively decreased the stemness and invasive properties of GBM-TS and showed a potential survival benefit in a mouse orthotopic xenograft model. Our findings suggest that targeting TS-forming cells by this dual inhibition of cellular bioenergetics warrants expedited clinical evaluation for the treatment of GBM.
The authors report a case of IgG4-related hypertrophic pachymeningitis that involved cerebral parenchyma. The mass was removed surgically. Histopathological studies showed diffuse infiltration of lymphoplasmacytic cells without evidence of Langerhans histiocytes or meningothelial cells. Immunoglobulin G4 was strongly positive on immunohistochemical staining. The Gd-enhanced lesion deep inside brain parenchyma was completely resolved after 3 months of oral corticosteroid medication. A nodular typ
The authors achieved good results by using extended TSS for the removal of suprasellar craniopharyngiomas. Endoscopy-assisted microscopic extended TSS harnesses the advantages of a microscope as well as those of an endoscope. Surgeons should consider using the advantages of both surgical modalities to achieve the best result possible.
Radiomic features may be useful biomarkers to predict the DA response in prolactinoma patients.
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