Sungkyunkwan University · Biochemistry, Genetics and Molecular Biology
Professor Eun-Kyung Lim's research lab specializes in the development of smart theranostic nanomaterials for precision medicine and environmental safety. The lab focuses on designing pH-responsive and stimuli-sensitive nanocarriers for targeted cancer therapy, integrating magnetic resonance imaging (MRI) with drug delivery to enable real-time monitoring and optimization of treatment. Additionally, the lab develops colorimetric and fluorescent nanoprobes for rapid detection of biological and environmental threats, including cancer biomarkers, biogenic amines in spoiled food, and pathogens like African swine fever virus. The overarching goal is to create multifunctional nanosystems that enhance diagnostic accuracy, therapeutic efficacy, and patient safety.
Figures are computed from collected data and may differ slightly.
Theranostics as a treatment strategy for individual patients encompasses a wide range of subjects, including personalized medicine, pharmacogenomics, and molecular imaging, in order to develop an efficient new targeted therapy and optimize drug selection via a better molecular understanding. Furthermore, theranostics aims to monitor the response to the treatment, to increase drug efficacy and safety, and to eliminate the unnecessary treatment of patients, resulting in significant cost savings fo
pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug release kinetics of the DMNPs, combined with the nanoparticle accumulation pattern in tumor cells, can be monitored by magnetic resonance imaging (MRI) to guide decisions regarding the optimization of drug dosing schedules.
Smart drug delivery systems that are triggered by environmental conditions have been developed to enhance cancer therapeutic efficacy while limiting unwanted effects. Because cancer exhibits abnormally high local acidities compared to normal tissues (pH 7.4) due to Warburg effects, pH-sensitive systems have been researched for effective cancer therapy. Chitosan-based intelligent theragnosis nanocomposites, N-naphthyl-O-dimethymaleoyl chitosan-based drug-loaded magnetic nanoparticles (NChitosan-D
Ingesting large quantities of biogenic amines (BAs), which are released from spoiled foods, can have adverse side effects on the human body. Herein, we developed a colorimetric sensor using polydiacetylene (PDA)-based hydrogel beads that change color upon binding with BAs, thereby conveniently checking whether food is spoiled due to improper storage and distribution. The colorimetric sensor is fabricated by mixing PDA liposomes with an alginate solution. PDA undergoes a color change from blue to
Gold nanoparticle-conjugated fluorescent hydroxyapatite (AuFHAp) was developed as a smart nanoprobe for measuring alkaline phosphatase (ALP) activity. AuFHAp showed NIR fluorescence due to the hydrolysis of its phosphate groups by ALP. In addition, gold nanoparticles help reduce the nonspecific signal by absorbing nonspecific fluorescence. Through in vitro tests, we confirmed that the AuFHAp probe was capable of detecting ALP levels related to osteoblast activity in living cells with high fluore
African swine fever virus (ASFV) causes a highly contagious and fatal disease affecting both domesticated and wild pigs. Substandard therapies and inadequate vaccinations cause severe economic damages from pig culling and removal of infected carcasses. Therefore, there is an urgent need to develop a rapid point-of-use approach that assists in avoiding the spread of ASFV and reducing economic loss. In this study, we developed a colorimetric sensing platform based on dual enzymatic amplification t
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