The University of Osaka · Chemistry
Professor Farzad Zamani's research lab specializes in the development of advanced functional materials and innovative catalytic systems for sustainable synthesis and biomedical applications. The lab focuses on metal–organic frameworks (MOFs), heterogeneous catalysts, and organoboron reagents for regio- and enantioselective transformations, with applications in the synthesis of complex organic molecules and bioactive compounds. Recent work emphasizes the design of selective RNA-binding agents and the use of gold- and zinc-catalyzed cascades for the efficient construction of heterocycles. The lab integrates experimental and computational methods to elucidate reaction mechanisms and optimize catalytic performance.
Figures are computed from collected data and may differ slightly.
Metal–organic frameworks (MOFs) offering abundant catalytic sites in highly ordered crystalline skeletons have recently received considerable attention as green platforms for multicomponent reactions, which are discussed in this review.
Allenyl- and propargylboronates have emerged as versatile reagents to effect regioselective propargylation or allenylation reactions of aldehydes, ketones, imines, and iminium ions. These boron-derived reagents have the ability to undergo transmetalation reactions with other metals (Ag, Cu, In, and Zn), often using only catalytic amounts of these metals, leading to more facile and highly regioselective reactions. Enantioselective organocatalyzed reactions have also been developed using, chiral
A synthesis of unconjugated (E)-enediynes from allenyl amino alcohols is reported and their gold-catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones has been developed. Experimental and computational studies support the reaction proceeding via a dual-gold σ,π-activation mode, involving a key gold-vinylidene- and allenyl-gold-containing intermediate.
Lysine (Lys) immobilized on zeolite 4A was prepared by a simple adsorption method. The physical and chemical properties of Lys/zeolite 4A were investigated by X-ray diffraction (XRD), FT-IR, Brunauer-Emmett-Teller (BET), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and UV-vis. The obtained organic-inorganic composite was effectively employed as a heterogeneous basic catalyst for synthesis of <TEX>${\alpha},{\beta}$</TEX>-unsaturated carbonyl compounds. No by-product
The simultaneous control of diastereoselectivity and regioselectivity in Zn-catalyzed allenylation reactions of N-protected l-α-amino aldehydes is reported. A reversal in diastereoselectivity could be realized by variation of the α-amino aldehyde protecting groups. A range of 1-allenyl-2-amino alcohols were obtained with excellent regioselectivity and converted to oxazolidinones and dihydrofurans. Many of which could be isolated as single diastereoisomers and without significant erosion of ee, m
RNAs are involved in an enormous range of cellular processes, including gene regulation, protein synthesis, and cell differentiation, and dysfunctional RNAs are associated with disorders such as cancers, neurodegenerative diseases, and viral infections. Thus, the identification of compounds with the ability to bind RNAs and modulate their functions is an exciting approach for developing next-generation therapies. Numerous RNA-binding agents have been reported over the past decade, but the design
In this study, polymer-grafted magnetic nanoparticles containing chromium(iii) ions incorporated onto Fe3O4/mercaptopropanoic acid-poly(2-hydroxyethyl acrylate) (Fe3O4/MPA-PHEA-Cr) was prepared via a simple and in situ method. The obtained magnetic nanocomposite exhibited a high catalytic activity and excellent selectivity in the aerobic oxidation of alcohols under solvent-free conditions. The magnetic catalyst could also be separated by an external magnet and reused seven times without any sign
Abstract A synthesis of unconjugated ( E )‐enediynes from allenyl amino alcohols is reported and their gold‐catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones has been developed. Experimental and computational studies support the reaction proceeding via a dual‐gold σ,π‐activation mode, involving a key gold‐vinylidene‐ and allenyl‐gold‐containing intermediate.
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