Sungkyunkwan University · Medicine
Professor Gyuri Kim's research lab focuses on the interplay between skeletal muscle metabolism, aging, and metabolic diseases, with a particular emphasis on nonalcoholic fatty liver disease (NAFLD), metabolic syndrome, and cardiometabolic health in middle-aged and older adults. The lab investigates how changes in skeletal muscle mass and body composition influence the development and progression of chronic conditions such as type 2 diabetes, hepatocellular carcinoma, and diastolic dysfunction. Utilizing longitudinal cohort studies and advanced clinical metrics like continuous glucose monitoring (CGM), the lab explores the role of myokines and muscle-derived signaling in systemic metabolic regulation. A key research direction involves identifying modifiable factors—such as muscle mass preservation and statin use—that may mitigate long-term complications in metabolic disease.
Figures are computed from collected data and may differ slightly.
Nonalcoholic fatty liver disease (NAFLD) has been associated with relative skeletal muscle mass in several cross-sectional studies. We explored the effects of relative skeletal muscle mass and changes in relative muscle mass over time on the development of incident NAFLD or the resolution of baseline NAFLD in a large, longitudinal, population-based 7-year cohort study. We included 12,624 subjects without baseline NAFLD and 2943 subjects with baseline NAFLD who underwent health check-up examinati
Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of
An increase in relative skeletal muscle mass over time has a potential preventive effect on developing metabolic syndrome, independently of baseline skeletal muscle mass and glycometabolic parameters.
<b><i>Background:</i></b> As the use of continuous glucose monitoring (CGM) has increased, time in range (TIR) and other core CGM metrics are now emerging as the core metrics for clinical targets and assessing diabetic complications, beyond HbA1c. This study investigated the association between the CGM-derived TIR, hyperglycemia, hypoglycemia metrics, and albuminuria. <b><i>Methods:</i></b> A total of 866 subjects with type 2 diabetes who underwent 3 or 6 days of CGM and had urinary albumin-to-c
Relationship on new statin use and the risk of hepatocellular carcinoma (HCC) in patients with incident type 2 diabetes mellitus (T2DM), who might be at the risk of developing HCC, is uncertained. A nationwide population-based nested case-control study was conducted within the National Health Insurance Service National Sample Cohort 2002-2013 in Korea. Newly prescribed statin after newly diagnosed T2DM was defined as statin use. Controls were matched to case patients on age, sex, follow-up time,
Our findings demonstrate that lower skeletal muscle mass and sarcopenic obesity are strongly associated with diastolic dysfunction in middle-aged and older adults.
Our findings indicate visceral adiposity is strongly associated with the alteration of myocardial glucose uptake evaluated by (18)FDG-PET, and its association further relates to T2DM.
The presence of significant liver fibrosis assessed via TE was independently associated with low BMD in NAFLD subjects.
NCT01404676.
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