Yonsei University · Medicine
Professor Han Sang Kim's research lab focuses on translational biomedical research with a strong emphasis on identifying molecular biomarkers and therapeutic targets in cancer and inflammatory diseases. The lab integrates multi-omics data, including genomics and gene set analysis, to uncover key pathways involved in radiosensitivity and drug response, particularly in head and neck cancers. Additionally, the lab explores pharmacogenomics to personalize therapy, as seen in studies on thiopurine-induced toxicity and targeted agents like dacomitinib. The lab also contributes to clinical pain management strategies and has a minor but notable foray into robotics engineering for precision applications in medical devices.
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Integration of four different microarray experiments and gene selection using gene set analysis discovered possible target genes and pathways relevant to radiosensitivity. Our results suggested that the identified genes are candidates for radiosensitivity biomarkers and that integrin signaling via adhesion molecules could be a target for radiosensitization.
Dacomitinib demonstrated clinical efficacy with manageable toxicity in platinum-failed R/M-SCCHN patients. Screening of PI3K pathway mutation and inflammatory cytokine expression may help identify which R/M-SCCHN patients are likely to gain benefit from dacomitinib.
In recent robotics research, the Stewart platform has been increasingly studied for possible use as a machine tool in view of the advantages of high stiffness and accuracy over serial-type manipulators. In designing and controlling a machine tool, accuracy is one of the most important factors to be considered. This article presents the development of methods of the forward and inverse error bound analyses of the Stewart platform. The forward error bound analysis is used to find the error bound o
Standardized pain education using nursing specialists is an efficient way to improve not only pain itself but also anxiety, depression, performance, and QoL. The addition of telemonitoring helps to improve pain management in the outpatient setting.
Periodontal disease, including periodontitis, was associated with increased risk of cancer, which persisted after controlling for confounding factors. Further prospective research is warranted to establish a causal relationship.
The results suggest that the hypomorphic <i>FTO</i> p.A134T variant is associated with thiopurine-induced leukopenia. These results shed light on the novel physiological role of FTO and provide a potential pharmacogenetic biomarker for thiopurine therapy.
Our findings demonstrate the feasibility of evDNA as a complementary tool to aid current methods of patient evaluation in the diagnosis and surveillance of colon cancer.
MET amplification and Met overexpression were positively correlated in GC. MET status should be re-evaluated in GC patients with liver metastasis, especially for metachronous metastasis.
Consolidation chemotherapy using paclitaxel/carboplatin may be inefficient and relatively toxic to advanced-stage epithelial ovarian cancer patients with complete response to six cycles of the same chemotherapy after surgery.
The presence and size of liver tumors, liver function, and NLR are key factors determining the response to nivolumab in aHCC. These clinical factors should be considered when treating patients with advanced HCC with PD-1 blockade.
Adenocarcinoma arising from the ampulla of Vater is a rare disease and has limited data regarding outcome of chemotherapy. The ampulla of Vater is a heterogeneous junctional structure located at the union of the common bile duct, the pancreatic duct, and the small intestine. Thus, ampullary adenocarcinoma is classified as either intestinal type or pancreatobiliary type. We investigated the efficacy of the XELOX (capecitabine plus oxaliplatin) chemotherapy in patients with recurrent or metastatic
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