Seoul National University · Medicine
Professor Han Suk Ryu's research lab specializes in molecular oncology and cancer diagnostics, with a focus on identifying novel biomarkers and immune microenvironment regulators in thyroid and liver cancers. The lab investigates key signaling molecules such as CXCL12, IDO, and SIRT1, aiming to improve diagnostic accuracy and understand immune evasion mechanisms in papillary thyroid cancer (PTC) and hepatocellular carcinoma. Their work integrates immunohistochemistry, molecular pathology, and translational research to develop supplementary diagnostic tools and explore therapeutic targets.
Figures are computed from collected data and may differ slightly.
Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD<sup>+</sup>) which regulates cellular energy metabolism. Except for its role in the production of adenosine triphosphate (ATP), NAD<sup>+</sup> acts as a substrate for several enzymes including sirtuin 1 (SIRT1) and poly ADP-ribose polymerase 1 (PARP1). Notably, NAM is an inhibitor of both SIRT1 and PARP1. Accumulating evidence suggests that NAM plays a role in cancer preve
Aims and background Differential diagnosis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma is sometimes difficult to accurately perform. Methods Eight markers including cytokeratin 7 (CK7), cytokeratin 19 (CK19), MOC31, CD10, glypican 3 (GPC3), claudin 4, biglycan and high mobility group A1 (HMGA1) were immunohistochemically stained in samples from 179 surgically resected hepatocellular carcinomas and 127 intrahepatic cholangiocarcinomas, and the rates of marker expression were s
Although the reviewer should be aware of distinctive cytomorphological alterations, the SP technique is reliable for the evaluation of breast lesions with the advantage of easy interpretation and a diagnostic accuracy equivalent to CS.
IDO expression and infiltration of FOXP3+ Treg cells were closely related to each other and were associated with aggressive features of PTMC, suggesting that disruption of antitumor immunity by IDO expression, and thus, infiltration of FOXP3+ Treg cells may contribute to tumor progression in PTMC.
Our findings indicate that CXCL12 might serve as an effective novel supplementary diagnostic marker for PTC.
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