Seoul National University · Medicine
Professor Hee Chan Kim's research lab specializes in biomedical microsystems and bioelectrical engineering, focusing on the development of advanced diagnostic technologies using nanomaterials, microfluidics, and computational modeling. Key research directions include label-free detection of circulating tumor cells via impedance sensing, miniaturized implantable biosensors for neural and cardiac monitoring, and AI-driven reconstruction of physiological signals such as 12-lead ECGs from wearable patch devices. The lab also investigates fundamental electrochemical phenomena in nanoporous structures to enable next-generation point-of-care diagnostics and implantable medical devices.
Figures are computed from collected data and may differ slightly.
Analytical applications and the underlying principles of unique electrochemistry in nanoporous structures are reviewed and discussed. In addition to the conventional concept of enlarged surface area, the structural effects of nanoporous materials can play significant roles such as discriminative electrokinetics, the nano-confinement effect, electrical double layer overlapping, ion-selective impedance, etc. The applications described in this review article include solid-state pH sensors, miniatur
The white blood cell differential count of the bone marrow provides information concerning the distribution of immature and mature cells within maturation stages. The results of such examinations are important for the diagnosis of various diseases and for follow-up care after chemotherapy. However, manual, labor-intensive methods to determine the differential count lead to inter- and intra-variations among the results obtained by hematologists. Therefore, an automated system to conduct the white
Quantification of circulating tumor cells (CTCs) in blood samples is believed to provide valuable evidence of cancer progression, cancer activity status, response to therapy in patients with metastatic cancer, and possible cancer diagnosis. Recently, a number of researchers reported that CTCs tend to lose their epithelial cell adhesion molecule (EpCAM) by an epithelial-mesenchymal transition (EMT). As such, label-free CTC detection methods are attracting worldwide attention. Here, we describe a
Reconstructing a standard 12-lead electrocardiogram (ECG) from signals received from electrodes packed into a patch-type device is a challenging task in the field of medical instrumentation. All attempts to obtain a clinically valid 12-lead ECG using a patch-type device were not satisfactory. In this study, we designed the hardware for a three-lead patch-type ECG device and employed a long short-term memory (LSTM) network that can overcome the limitations of the linear regression algorithm used
A new mathematical method was developed to estimate the local epicardial deformation, wall thickness, and the regional circumferential and longitudinal wall stress using biplane coronary cineangiograms. In this method, the motion images of the coronary artery bifurcation points were used as natural landmarks for the kinematic analysis of the ventricular deformation. In four dogs and a normal patient's coronary cineangiograms, the estimation results show the validity of the present analysis, comp
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