Waseda University · Engineering
Professor Hideyuki Murakami's research lab specializes in cardiovascular and vascular biology, with a focus on the pathophysiological roles of bioactive peptides and hormones in hypertension, insulin resistance, and atherosclerosis. The lab investigates the kallikrein-kinin system and renin-angiotensin system in regulating vascular smooth muscle cell function and baroreflex sensitivity, particularly in heart failure models. Additionally, the lab explores materials science aspects, including the effects of platinum group metals on the microstructure and phase stability of nickel-based superalloys. These interdisciplinary studies bridge molecular mechanisms in cardiovascular disease with advanced materials development.
Figures are computed from collected data and may differ slightly.
Insulin resistance is one of the major risk factors associated with development of hypertension and atherosclerosis. Recent studies have shown that adiponectin, an adipocyte-derived hormone, may be involved in insulin resistance and development of atherosclerosis in diabetes patients. The aim of this study was to examine adiponectin levels in patients with essential hypertension to determine the relationships between adiponectin levels and insulin sensitivity and to examine the relationship of a
Tissue kallikrein cleaves kininogen substrate to produce vasoactive kinin peptides that have been implicated in the proliferation of vascular smooth muscle cells (VSMCs). To explore potential roles of the kallikrein-kinin system in vascular biology, we evaluated the effects of adenovirus-mediated human kallikrein gene delivery on the growth of primary cultured VSMCs and in balloon-injured rat artery in vivo. Kallikrein gene transfer into cultured rat VSMCs resulted in time-dependent secretion of
The effects of platinum group metals (PGMs) addition on microscopic characteristics of Ni-Al-PGM ternary and Ni-base single crystal superalloys were investigated. Several Ni-19at%Al-Xat% PGM (PGM: Ru, Rh, Pd, Ir and Pt) ternary alloys were prepared by arc-melting in order to understand the distribution of PGMs in y and y ' two phases. It is found from differential thermal analysis (DTA) that among PGMs, Ir and Ru increase the melting points whereas Pt and Pd decrease the melting points. These al
Because the renin-angiotensin system is activated in heart failure, we hypothesized that angiotensin II (ANG II) plays a role in altering baroreflex sensitivity in the setting of heart failure. Accordingly, we evaluated the baroreflex control of heart rate (HR) in conscious, chronically instrumented rabbits in the normal state and after the establishment of heart failure. Heart failure was induced by rapid ventricular pacing at a rate of 360-380 beats/min for an average of 14.5 +/- 1.4 days. The
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