Keio University · Medicine
Professor Hirofumi Kawakubo's research lab specializes in surgical oncology with a focus on esophageal cancer, particularly the molecular mechanisms underlying carcinogenesis and the surgical management of early-stage disease. The lab investigates field cancerization in the esophagus through immunohistochemical and genetic analyses of biomarkers such as p53, cyclin D1, and pRB, aiming to understand the precancerous changes in esophageal epithelium. It also explores surgical innovations, including extended thoracic lymphadenectomy and minimally invasive esophagectomy, to improve lymph node retrieval and patient survival. The lab integrates molecular pathology with clinical surgery to enhance early diagnosis and curative treatment strategies for esophageal squamous cell carcinoma.
Figures are computed from collected data and may differ slightly.
Extended TMIE including thoracic duct resection increased the number of lymph nodes retrieved and was associated with improved survival in patients with cT1 N0 oesophageal squamous cell carcinoma.
Many molecular alterations occur in esophageal carcinogenesis; however, little is known about the molecular genetic events responsible for the development of carcinoma. We investigated the expression of ki67, p53, cyclin D1 and pRB in 105 biopsy specimens using immunohistochemistry from iodine unstained lesions as indicators of carcinogenesis of the esophagus. Also, the genetic alternation of esophageal dysplasia from patients with accompanying esophageal squamous cell carcinoma (ESCC) was exami
Esophageal cancer has one of the highest malignant potentials of any type of tumor. The 3-field lymph node dissection is the standard procedure in Japan for surgically curable esophageal cancer in the middle or upper thoracic esophagus. Minimally invasive esophagectomy is being increasingly performed in many countries, and several studies report its feasibility and curability; further, the magnifying effect of the thoracoscope is another distinct advantage. However, few studies have reported tha
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