The University of Tokyo · Medicine
Professor Hiromitsu Nakauchi's research lab specializes in stem cell biology, with a focus on hematopoietic stem cells (HSCs) and their role in lifelong blood cell production. The lab pioneers techniques for the isolation and characterization of HSCs using cell surface markers such as mCD34, enabling high-purity purification and functional analysis of individual stem cells. Their work has significantly advanced the understanding of HSC self-renewal and multilineage differentiation, with implications for regenerative medicine and transplantation therapies. The lab also explores the potential of stem cells in disease modeling and gene therapy applications.
Figures are computed from collected data and may differ slightly.
Hematopoietic stem cells (HSCs) supply all blood cells throughout life by making use of their self-renewal and multilineage differentiation capabilities. A monoclonal antibody raised to the mouse homolog of CD34 (mCD34) was used to purify mouse HSCs to near homogeneity. Unlike in humans, primitive adult mouse bone marrow HSCs were detected in the mCD34 low to negative fraction. Injection of a single mCD34(lo/-), c-Kit+, Sca-1(+), lineage markers negative (Lin-) cell resulted in long-term reconst
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