Kyoto University · Medicine
Professor Hiroshi Date's research lab specializes in translational and experimental thoracic oncology, with a focus on understanding the biological mechanisms underlying chemoresistance and metabolic reprogramming in lung cancer and thymic malignancies. The lab investigates hypoxia-inducible factors, glycolytic metabolism, and tumor microenvironment influences on treatment response and patient outcomes. Additionally, the lab explores innovative surgical and preservation strategies for thoracic organs, particularly in the context of lung transplantation and organ preservation. Their work bridges molecular oncology with clinical applications to improve survival and treatment efficacy in patients with advanced thoracic cancers and those requiring lung transplantation.
Figures are computed from collected data and may differ slightly.
In this study, PORT did not increase RFS or OS for stage II or III thymoma but increased RFS for stage II and III thymic carcinoma.
Although LDLLT patients were in a worse preoperative condition than CLT patients, LDLLT patients demonstrated survival rates similar to CLT patients. LDLLT is a viable option for patients too ill to survive a long waiting time for cadaveric donors.
Lung cancer treatment is difficult owing to chemoresistance. Hypoxia-inducible factor 1 (HIF-1) and HIF-1-induced glycolysis are correlated with chemoresistance; however, this is not evident in lung cancer. We investigated the effect of HIF-1α and carbonic anhydrase IX (CAIX), a transmembrane protein neutralizing intracellular acidosis, on chemoresistance and prognosis of lung cancer patients after induction chemoradiotherapy. Associations of HIF-1α, glucose transporter 1 (GLUT1), and CAIX with
The lung is the only organ to which oxygen may be supplied after its blood supply is stopped. Before this study, we were not certain whether lung cells were able to maintain aerobic metabolism with the oxygen in the alveoli during preservation. Excised rabbit lungs were used to measure changes in the concentration of oxygen and carbon dioxide in the airway and changes in glucose, glucose-6-phosphate, lactate, adenosine triphosphate, and phosphocreatine levels in the lung tissue during preservati
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