Ho Joong Kim
Seoul National University · Medicine
About the Lab
Professor Ho Joong Kim's research lab specializes in biomedical materials and regenerative medicine, focusing on the development of smart, biocompatible nanostructures for targeted drug delivery and tissue engineering. The lab explores supramolecular self-assembly systems, particularly those based on peptide and ethylene oxide-based molecules, to create dynamic, responsive materials for applications in ocular drug delivery and spinal surgery. A key innovation includes the use of nanodiamond-embedded contact lenses for sustained, enzyme-triggered release of glaucoma therapeutics, as well as the application of robotics and quality control analytics in spinal pedicle screw placement. The lab also investigates regenerative strategies using platelet-rich plasma and biomaterials to modulate inflammatory responses in intervertebral disc cells.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15During the past decade, supramolecular nanostructures produced via self-assembly processes have received considerable attention because these structures can lead to dynamic materials. Among these diverse self-assembly systems, the aqueous assemblies that result from the sophisticated design of molecular building blocks offer many potential applications for producing biocompatible materials that can be used for tissue regeneration, drug delivery, and ion channel regulation. Along this line, resea
Robotic-assisted pedicle screw placement was associated with fewer proximal facet joint violations and better convergence orientations.
Temporarily implanted devices, such as drug-loaded contact lenses, are emerging as the preferred treatment method for ocular diseases like glaucoma. Localizing the delivery of glaucoma drugs, such as timolol maleate (TM), can minimize adverse effects caused by systemic administration. Although eye drops and drug-soaked lenses allow for local treatment, their utility is limited by burst release and a lack of sustained therapeutic delivery. Additionally, wet transportation and storage of drug-soak
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
First, this study demonstrates the adequacy of quality control of robot-assisted pedicle screw fixation even early in the application period based on the CUSUM analysis. Second, the CUSUM test can be a useful tool for monitoring of the quality of procedures related with spine surgery.
The purpose of this study was to investigate the anti-inflammatory effect of platelet-rich plasma (PRP) with collagen matrix on human nucleus pulposus (NP) cell in response to pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1). NP cells from human disks were cultured in a monolayer and maintained in the collagen matrix prior to the addition of recombinant human IL-1 and TNF-α. After applying IL-1 and TNF-α, PRP prepared by using a commercially availab
In models of 1-segment lumbar fusion surgery, the positions of pedicle screws were closely linked with corresponding disc stresses and facet contact forces. However, even in cases of facet violation by pedicle screws, removal of the pedicle screw after fusion completion can reduce facet contract forces and disc stresses under both extension and torsional moments.
The current study highlights that patients with symptomatic LSS have a risk of a fall comparable with the patients who had degenerative KOA based on the results of functional mobility tests (SMT, STS, AST, and TUGT).
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A poor surgical outcome would be inevitable because of the worsening of symptoms owing to the natural history of PD. Therefore, our current study suggested surgical indication should be exercised cautiously in the patients with PD and spinal stenosis.
Research Areas
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