Korea University · Medicine
Professor Hye Jin Yoo's research lab focuses on the pathophysiological roles of adipokines, hepatokines, and other metabolic hormones in the development of cardiovascular disease and metabolic syndrome. The lab investigates how adipose tissue and liver-derived signaling molecules—such as omentin-1, chemerin, fibroblast growth factor 21, fetuin-A, and selenoprotein P—influence arterial stiffness, endothelial dysfunction, and atherosclerosis, particularly in the context of type 2 diabetes and non-alcoholic fatty liver disease. Their work emphasizes the translational potential of these biomarkers as independent risk predictors and therapeutic targets. The lab integrates clinical epidemiology with molecular mechanisms to uncover novel pathways linking metabolic dysfunction to cardiovascular outcomes.
Figures are computed from collected data and may differ slightly.
Circulating omentin-1 level was independently correlated with arterial stiffness and carotid plaque in type 2 diabetes, even after adjusting for other cardiovascular risk factors and detailed medication history.
Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the rep
ClinicalTrials.gov NCT01668888.
Clinicaltrials.gov NCT01594710.
The traditional perception of adipose tissue as a storage organ of fatty acids has been replaced by the notion that adipose tissue is an active endocrine organ, releasing various adipokines that are involved in the pathogenesis of obesity-related metabolic disturbances. Obesity is a well-known risk factor for atherosclerosis, and accelerates atherosclerosis by many mechanisms such as increase in blood pressure and glucose level, abnormal lipid profiles, and systemic inflammation. Furthermore, gr
The circulating chemerin level was an independent risk factor for arterial stiffness even after adjusting for other cardiovascular risk factors.
Progranulin efficiently inhibited LPS-mediated pro-inflammatory signaling in endothelial cells through activation of the Akt/eNOS pathway and attenuation of the NF-κB pathway, suggesting its protective roles in vascular endothelium against inflammatory reaction underlying atherosclerosis.
The simple anthropometric parameters, such as waist circumference and waist-to-height ratio, are as useful as DXA and CT for predicting NAFLD in Korean adults.
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