Ulsan National Institute of Science and Technology · Medicine
Professor HyungJoon Cho's research lab specializes in advanced biomedical imaging and functional materials, focusing on the development and application of multimodal MRI and PET techniques for in vivo tumor characterization and neurodegenerative disease monitoring. The lab investigates microvascular architecture in neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease using high-field MRI and relaxometry, while also pioneering novel nanomaterials for functional applications, including mechanically reinforced silica aerogels and stimuli-responsive emulsion templates. A central theme is the translation of biophysical and molecular imaging biomarkers into clinical and preclinical tools for early diagnosis and personalized therapy.
Figures are computed from collected data and may differ slightly.
In vivo knowledge of the spatial distribution of viable, necrotic, and hypoxic areas can provide prognostic information about the risk of developing metastases and regional radiation sensitivity and may be used potentially for localized dose escalation in radiation treatment. In this study, multimodality in vivo magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging using stereotactic fiduciary markers in the Dunning R3327-AT prostate tumor were performed, focusing on th
We have measured the decay of NMR multiple quantum coherence intensities both under the internal dipolar Hamiltonian as well as when this interaction is effectively averaged to zero, in the cubic calcium fluoride $(\mathrm{Ca}{\mathrm{F}}_{2})$ spin system and the pseudo-one-dimensional system of fluoroapatite. In calcium fluoride the decay rates depend both on the number of correlated spins in the cluster, as well as on the coherence number. For smaller clusters, the decays depend strongly on c
Visualizing gradual changes in neuromelanin distribution within the substantia nigra is an important metric used to monitor the progression of Parkinsonism. This study aimed to identify the origin of the mismatch region between magnetic resonance transverse relaxation times (T<sub>2</sub> and T<sub>2</sub>*) in the substantia nigra and investigate its feasibility and implications for in vivo detection of neuromelanin as a clinical biomarker. The relationships between neuromelanin distribution as
Synthesis of silica aerogel insulators with ultralight weight and strong mechanical properties using a simplified technique remains challenging for functional soft materials. This study introduces a promising method for the fabrication of mechanically reinforced ultralight silica aerogels by employing attractive silica nanolace (ASNLs)-armored Pickering emulsion templates. For this, silica nanolaces (SiNLs) are fabricated by surrounding a cellulose nanofiber with necklace-shaped silica nanospher
3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2020;51:1369-1381.
In this study, we quantified perfusion deficits using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with an extravasating contrast agent (CA). We also investigated the efficacy of leakage compensation from CA pre-load in brains from post-ischemic rat models without significant dynamic contrast-enhanced MRI (DCE-MRI)-derived vessel wall permeability. DSC measurements were obtained using fast (0.3 s) echo-planar imaging in both normal rats and rats with transient middle caro
Temporal resolution-improved CS-TSE provides practical subsecond (0.96s) calibration-free dynamic MR quantification of high Gd concentration. J. Magn. Reson. Imaging 2016;44:138-147.
Structural and functional features of various cerebral cortices have been extensively explored in neuroscience research. We used manganese-enhanced MRI, a non-invasive method for examining stimulus-dependent activity in the whole brain, to investigate the activity in the layers of primary cortices and sensory, such as auditory and olfactory, pathways under acoustic stimulation. Male Sprague-Dawley rats, either with or without exposure to auditory stimulation, were scanned before and 24-29 hour a
The spatial heterogeneity in the temporal occurrence of pseudo-normalization of MR apparent diffusion coefficient values for ischemic lesions may be related to morphological and functional vascular remodeling. As the area of accelerated pseudo-normalization tends to expand faster and more extensively into the chronic stage, detailed vascular characterization of such areas is necessary. During the subacute stage of transient middle cerebral artery occlusion rat models, the morphological size of t
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