Sungkyunkwan University · Medicine
Professor Jae Hoon Chung's research lab specializes in thyroid cancer diagnostics and personalized management, focusing on molecular diagnostics, tumor progression monitoring, and recurrence prediction in papillary thyroid cancer (PTC). The lab develops and applies highly sensitive molecular assays like MEMO sequencing to detect BRAF mutations in fine-needle aspiration cytology, improving early detection and risk stratification. They also investigate tumor volume dynamics during active surveillance and the clinicopathologic factors influencing recurrence patterns, aiming to optimize treatment strategies and long-term follow-up. Their work bridges molecular pathology with clinical decision-making to enhance patient outcomes.
Figures are computed from collected data and may differ slightly.
A significant number of PTMCs grow during active surveillance, and tumor volume change is a more sensitive means of evaluating tumor growth. Active surveillance can be carefully applied for selected patients. Although it is not contraindicated, it should be applied more cautiously for younger patients.
Highly sensitive and specific molecular assays such as MEMO sequencing are optimal for detecting the BRAF mutations in thyroid FNAC because these techniques can detect PTC that might be missed by cytology or less sensitive molecular assays.
Patterns of recurrence after complete PTC resection are variable and associated with specific clinicopathologic factors. Understanding the timing and patterns of recurrence may lead to more effective adjuvant treatment and improved long-term follow-up strategies.
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