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Jae-Jin Song

Seoul National University · Neuroscience

About the Lab

Professor Jae-Jin Song's research lab focuses on redox signaling and stress response mechanisms in cancer and neurological disorders. The lab investigates how oxidative stress and redox-sensitive proteins—such as glutaredoxin (GRX) and thioredoxin (TRX)—regulate key signaling pathways like ASK1-JNK1 in response to metabolic stress, particularly glucose deprivation. The lab also explores the role of these pathways in neurodegenerative and neuropsychiatric conditions, including Parkinson’s disease, tinnitus, and depression, using electrophysiological and neuroimaging approaches. Additionally, the lab evaluates neuromodulation techniques such as transcranial direct current stimulation (tDCS) for tinnitus management through clinical and meta-analytic studies.

redox signalingASK1-JNK1 pathwayglucose deprivationneuromodulationtinnitus

Research Overview

Papers
212
Total Citations
4,539
Papers (5y)
61
Primary Field
Neuroscience

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
61total
2021
2022
2023
2024
2025
Citations per year (5y)
1,109total
20212022202320242025

Selected Papers

15
1
Article|241 citations·2018
Thalamocortical dysrhythmia detected by machine learning
Sven Vanneste, Jae‐Jin Song, Dirk De Ridder
SJR Q1FWCI 13.3Nature CommunicationsOA

Thalamocortical dysrhythmia (TCD) is a model proposed to explain divergent neurological disorders. It is characterized by a common oscillatory pattern in which resting-state alpha activity is replaced by cross-frequency coupling of low- and high-frequency oscillations. We undertook a data-driven approach using support vector machine learning for analyzing resting-state electroencephalography oscillatory patterns in patients with Parkinson's disease, neuropathic pain, tinnitus, and depression. We

Cognitive NeuroscienceNeuroscience
2
Review|88 citations·2012
Transcranial Direct Current Stimulation in Tinnitus Patients: A Systemic Review and Meta-Analysis
Jae‐Jin Song, Sven Vanneste, Paul Van de Heyning, Dirk De Ridder
SJR Q2FWCI 4.4The Scientific World JOURNALOA

Although transcranial direct current stimulation (tDCS) has already been used to manage tinnitus patients, paucity of reports and variations in protocols preclude a comprehensive understanding. Hence, we conducted a meta-analysis based on systemic review to assess effectiveness of tDCS in tinnitus management and to compare stimulation parameters. PubMed was searched for tDCS studies in tinnitus. For randomized controlled trials (RCTs), a meta-analysis was performed. A total of 17 studies were id

NeurologyNeuroscience
3
Review|88 citations·2012
Mapping Tinnitus-Related Brain Activation: An Activation-Likelihood Estimation Metaanalysis of PET Studies
Jae‐Jin Song, Dirk De Ridder, Paul Van de Heyning, Sven Vanneste
SJR Q1FWCI 4.3Journal of Nuclear MedicineOA

This study proves that PET is a useful modality for tinnitus research and solidifies human tinnitus research itself by confirming previously described brain areas involved in the generation and maintenance of tinnitus.

Sensory SystemsNeuroscience
4
Article|76 citations·2015
Dysfunctional Noise Cancelling of the Rostral Anterior Cingulate Cortex in Tinnitus Patients
Jae‐Jin Song, Sven Vanneste, Dirk De Ridder
SJR Q1FWCI 3.8PLoS ONEOA

These results may designate the role of the rostral ACC as the core of the descending noise cancellation system, and thus dysfunction of the rostral ACC may result in perception of tinnitus. The present study also opens a possibility of tinnitus modulation by neuromodulatory approaches targeting the rostral ACC.

Sensory SystemsNeuroscience
5
Article|73 citations·2013
Neural substrates predicting improvement of tinnitus after cochlear implantation in patients with single-sided deafness
Jae‐Jin Song, Andrea Kleine Punte, Dirk De Ridder, Sven Vanneste, Paul Van de Heyning
SJR Q2FWCI 4.8Hearing Research
Cognitive NeuroscienceNeuroscience
6
Article|69 citations·2013
Hyperacusis-associated pathological resting-state brain oscillations in the tinnitus brain: a hyperresponsiveness network with paradoxically inactive auditory cortex
Jae‐Jin Song, Dirk De Ridder, Nathan Weisz, Winfried Schlee, Paul Van de Heyning, Sven Vanneste
SJR Q1FWCI 3.9Brain Structure and Function
Sensory SystemsNeuroscience
7
Article|69 citations·2009
Unilateral Sensorineural Hearing Loss in Children
Jae‐Jin Song, Hyo Geun Choi, Seung Ha Oh, Sun O Chang, Chong Sun Kim, Jun Ho Lee
SJR Q1FWCI 1.4Otology & Neurotology

Based on the results, we propose all children with USNHL should have a TBCT scan because management, including genetic counseling and prognostic predictions of these cases, may be significantly influenced by the CT outcome. Moreover, the non-negligible rate of progressive nature of ipsilateral and contralateral SNHL in normal-looking TBCT group and in groups with inner ear malformations mandates longitudinal audiologic assessments for both ears

Sensory SystemsNeuroscience
8
Article|67 citations·2013
Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus
Jae‐Jin Song, Sven Vanneste, Winfried Schlee, Paul Van de Heyning, Dirk De Ridder
SJR Q1FWCI 2.9Brain Structure and Function
Sensory SystemsNeuroscience
9
Article|60 citations·2011
Anxiolytics reduce residual dizziness after successful canalith repositioning maneuvers in benign paroxysmal positional vertigo
Hahn Jin Jung, Ja‐Won Koo, Chong Sun Kim, Ji Soo Kim, Jae‐Jin Song
SJR Q2FWCI 0.9Acta Oto-Laryngologica

Both groups demonstrated a significant improvement in DHI scores. However, the medication group showed significantly greater decrease in the functional (p = 0.018) and emotional (p = 0.030) subscale scores, as well as in the total DHI (p = 0.038) score.

NeurologyNeuroscience
10
Article|56 citations·2017
No auditory experience, no tinnitus: Lessons from subjects with congenital- and acquired single-sided deafness
Sang‐Yeon Lee, Dong Woo Nam, Ja‐Won Koo, Dirk De Ridder, Sven Vanneste, Jae‐Jin Song
SJR Q2FWCI 4.0Hearing Research
Sensory SystemsNeuroscience
11
Article|52 citations·2013
“Distressed aging”: the differences in brain activity between early- and late-onset tinnitus
Jae‐Jin Song, Dirk De Ridder, Winfried Schlee, Paul Van de Heyning, Sven Vanneste
SJR Q1FWCI 3.9Neurobiology of Aging
Sensory SystemsNeuroscience
12
Article|50 citations·2015
Sinus Wall Resurfacing for Patients With Temporal Bone Venous Sinus Diverticulum and Ipsilateral Pulsatile Tinnitus
Jae‐Jin Song, Young Jin Kim, So Young Kim, Yun Suk An, Kanghyeon Kim, Sang‐Yeon Lee, Ja‐Won Koo
SJR Q1FWCI 2.6Neurosurgery

PT resulting from either SSD or MFD-VS can be treated successfully with transmastoid resurfacing of the venous wall. Preoperative ipsilesional LFHL and the improvement of hearing threshold after surgical intervention may be preoperative and postoperative surrogate objective signatures of PT. To ensure the resolution of symptoms, secure reconstruction with firm materials and long-term follow-up are mandatory.

NeurologyNeuroscience
13
Article|49 citations·2014
Effects of congruent and incongruent visual cues on speech perception and brain activity in cochlear implant users
Jae‐Jin Song, Hyo‐Jeong Lee, Hyejin Kang, Dong Soo Lee, Sun O Chang, Seung Ha Oh
SJR Q1FWCI 7.2Brain Structure and Function
Experimental and Cognitive PsychologyPsychology
14
Article|49 citations·2016
Objectification and Differential Diagnosis of Vascular Pulsatile Tinnitus by Transcanal Sound Recording and Spectrotemporal Analysis
Jae‐Jin Song, Gwang Seok An, Inyong Choi, Dirk De Ridder, So Young Kim, Hyun Seok Choi, Joo Hyun Park, Byung Yoon Choi, Ja‐Won Koo, Kyogu Lee
SJR Q1FWCI 2.6Otology & Neurotology

The present diagnostic approach may provide additional information regarding the origins of VPT cases as well as an efficient and objective diagnostic method. Furthermore, this approach may aid in the determination of appropriate imaging modalities, treatment planning, and evaluation of treatment outcomes.

Sensory SystemsNeuroscience
15
Article|36 citations·2014
Pediatric tracheostomy revisited: A nine‐year experience using horizontal intercartilaginous incision
Jae‐Jin Song, Ik Joon Choi, Hyun‐Ha Chang, Dong Wook Kim, Hyoung Woo Chang, Gyeong‐Hun Park, Min‐Su Kim, Myung Whun Sung, J. Hun Hah
SJR Q1FWCI 2.9The Laryngoscope

4.

Pulmonary and Respiratory MedicineMedicine

Research Areas

NeurologySensory SystemsCognitive NeuroscienceOtorhinolaryngologyMolecular BiologyCellular and Molecular Neuroscience

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