Yonsei University · Medicine
Professor Jae Wook Jung's research lab specializes in comparative immunology and translational medicine, with a focus on understanding the adaptive immune system in teleost fish and its evolutionary parallels to mammalian immunity. The lab develops monoclonal antibodies and molecular tools to characterize T cell subsets—such as CD4 and CD8 T lymphocytes—in fish models like olive flounder, advancing insights into fish immune responses to viral infections. Additionally, the lab explores innate immune mechanisms in jawless vertebrates, particularly the variable lymphocyte receptors (VLRs) in hagfish and lamprey, with applications in recombinant antibody technology. The lab also contributes to clinical research, particularly in neurovascular and cardiovascular interventions, including endovascular thrombectomy outcomes and sedation strategies during percutaneous ASD closure procedures.
Figures are computed from collected data and may differ slightly.
The presence of CD4 T lymphocytes has been described for several teleost species, while many of the main T cell subsets have not been characterized at a cellular level, because of a lack of suitable tools for their identification, e.g., monoclonal antibodies (mAbs) against cell markers. We previously described the tissue distribution and immune response related to CD3ε and CD4-1 T cells in olive flounder (<i>Paralichthys oliveceus</i>) in response to a viral infection. In the present study, we s
In higher vertebrates, helper and cytotoxic T cells, referred to as CD4 and CD8 T lymphocytes, respectively, are mainly associated with adaptive immunity. The adaptive immune system in teleosts involves T cells equivalent to those found in mammals. We previously generated monoclonal antibodies (mAbs) against olive flounder (<i>Paralichthys olivaceus</i>) CD4 T cells, CD4-1 and CD4-2, and used these to describe the olive flounder's CD4 Tcell response during a viral infection. In the present study
The variable lymphocyte receptor (VLR) mediates the humoral immune response in jawless vertebrates, including lamprey (<i>Petromyzon marinus</i>) and hagfish (<i>Eptatretus burgeri</i>). Hagfish VLRBs are composed of leucine-rich repeat (LRR) modules, conjugated with a superhydrophobic C-terminal tail, which contributes to low levels of expression in recombinant protein technology. In this study, we screened Ag-specific VLRBs from hagfish immunized with nervous necrosis virus (NNV). The artifici
In this cohort study of patients with successful endovascular thrombectomy after stroke, MIBD within 24 hours after successful recanalization was associated with poor outcomes at 3 months. These findings suggested lowering systolic BP to below 100 mm Hg using BP medication might be harmful.
Atrial septal defect (ASD) is second common congenital heart disease that often leads to adult period. Intracardiac or transesophageal echocardiography (TEE) is essential for percutaneous closure of ASD using Amplatzer septal occluder. Dexmedetomidine (DEX), which is a highly selective α2-agonist, has sedative and analgesic properties without respiratory depression in the clinical dose range. We report percutaneous closure of ASD with TEE under DEX sedation.
Purpose: To investigate treatment options for local control of metastasisin the brain, we compared focal brain treatment (FBT)with or without whole brain radiotherapy (WBRT) vs. WBRT alone,for breast cancer patients with tumor relapse in the brain. We alsoevaluated treatment outcomes according to the subtypes. Methods:We conducted a retrospective review of breast cancer patientswith brain metastasis after primary surgery. All patients receivedat least one local treatment for brain metastasis. Su
Purpose: To report a case of compressive optic neuropathy due to breast cancer metastasis to the periorbital lesion 26 years after the treatment of primary cancer.\nCase summary: A 64-year-old female presented with headache, facial pain and visual disturbance in her left eye for four months. The patient had received chemotherapy and radiotherapy after left breast modified radical mastectomy for invasive ductal carcinoma 26 years previously, and right breast wide resection with axillary dissectio
In MMI patients, continuous ICP monitoring could be useful for detecting those with an increasing ICP trend that may be associated with unfavorable clinical outcomes.
Purpose: This study provides a standardized operative strategical algorithm that can be applied to patients with T1/T2 gallbladdercancer (GBC). Our aim was to determine the oncologic outcome of radical cholecystectomy with para-aortic lymph node dissectionwithout liver resection in T1/T2 GBC. Materials and Methods: From January 2005 to December 2017, 164 patients with GBC underwent operations by a single surgeonat Severance Hospital. A retrospective review was performed for 113 of these patients
Endovascular thrombectomy has a recanalization rate over 80%; however, approximately 50% of ischemic stroke patients still experience dependency or mortality. Recently, clinical trials demonstrated the benefits of administering neuroprotective agents prior to endovascular thrombectomy. Additionally, recent studies showed neuroprotective effects of mild hypercapnia in patients resuscitated after cardiac arrest. However, its efficacy in ischemic stroke remains unclear. We aimed to investigate whet
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