Yonsei University · Medicine
Professor Jae-Jin Kim's research lab specializes in neuropsychiatry and neuroimaging, focusing on the neural circuitry underlying psychiatric disorders such as obsessive-compulsive disorder (OCD), schizophrenia, and delirium. The lab investigates functional and structural brain abnormalities using advanced neuroimaging techniques like SPECT, fMRI, and EEG to uncover disruptions in frontal-subcortical, prefrontal-parietal, and whole-brain network connectivity. A key research direction involves linking these neurobiological findings to clinical symptoms, such as cognitive dysmetria in schizophrenia or inattention in delirium, and exploring potential metabolic and nutritional modulators like zinc in atopic dermatitis.
Figures are computed from collected data and may differ slightly.
Increased grey matter density of frontal-subcortical circuits, consonant with the hypermetabolic findings from functional imaging studies, seems to exist in patients with OCD, and cerebellar dysfunction may be involved in the pathophysiology of OCD.
rCBF abnormalities in patients with chronic schizophrenia are not due to chronicity of illness or the effects of medication. These results provide evidence that the primary neural abnormalities in schizophrenia may occur in cortical, cerebellar, and thalamic regions and that the dysfunction in these regions may explain the "loosening of associations" that Bleuler considered to be the fundamental cognitive phenotype of schizophrenia. These abnormalities can be reconceptualized as "cognitive dysme
The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia.
Zinc deficiency in patients with atopic dermatitis (AD) and the use of zinc supplementation is still controversial. We measured hair zinc levels in 58 children with AD and 43 controls (age range 2-14 years). We also investigated the efficacy of oral zinc supplementation in AD patients with low hair zinc levels by comparing eczema assessment severity index (EASI), transepidermal water loss (TEWL), and visual analogue scales for pruritus and sleep disturbance in patients receiving zinc supplementa
Delirium is characterized by inattention and other cognitive deficits, symptoms that have been associated with disturbed interactions between remote brain regions. Recent EEG studies confirm that disturbed global network topology may underlie the syndrome, but lack an anatomical basis. The aim of this study was to increase our understanding of the global organization of functional connectivity during delirium and to localize possible alterations. Resting-state fMRI data from 44 subjects were ana
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