Yonsei University · Dentistry
Professor Jae-Kook Cha's research lab specializes in oral implantology and regenerative dentistry, focusing on the treatment and prevention of peri-implantitis, alveolar ridge preservation, and guided bone regeneration. The lab investigates clinical and biomaterial-based strategies to enhance osseointegration, including the use of local antimicrobials like minocycline, growth factors such as BMP-2, and innovative grafting techniques. Key research directions include optimizing nonsurgical and surgical interventions for peri-implantitis, improving bone regeneration in compromised sites (e.g., posterior maxilla and sinus augmentation), and evaluating surface modifications of dental implants to enhance long-term outcomes. The lab combines clinical trials, in vitro studies, and animal models to translate findings into practical clinical applications.
Figures are computed from collected data and may differ slightly.
The purpose of this study was to determine the clinical, microbial, and radiographic effects of local minocycline combined with surgical treatment of peri-implantitis. Fifty patients with peri-implantitis were recruited, and surgical treatment with the local application of either minocycline or placebo ointment was performed. The application of minocycline was repeated with supragingival debridement at 1, 3, and 6 mo postoperatively. Plaque index, gingival index (GI), probing pocket depth (PPD),
Alveolar ridge preservation in the posterior maxilla maintained the vertical bone height more efficiently and resulted in less need for sinus augmentation procedures at 6 months compared to spontaneous healing.
Within the limitations of this in vitro investigation, the tested protocols induced different macroscopic alterations and surface roughness changes that varied in the thread and valley area.
BMP-2 in a BHC carrier, even at the low 0.1-mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.
Additive use of either MM or MC results in significantly higher treatment success rates compared to sole mechanical debridement in nonsurgical treatment of peri-implantitis. Moreover, MM contributes to a significantly greater reduction in the PPD compared to MC in deep pockets (cris.nih.go.kr KCT0004557).
It was conjectured that intentional cortical perforation of the recipient bed and the ABB might enhance the initial angiogenesis and the integration of the graft.
It can be suggested that Osteon may have predictable result when it was used as a grafting material for sinus floor augmentation.
A wide restorative angle increases MBL and impairs the integrity of the junctional epithelium of the implant supracrestal complex.
Oral administration of MAEC would have a potential to reduce gingival inflammation clinically and immunologically in the patients with gingivitis and incipient periodontitis.
BCP can achieve proper dimensional stability with minimal reduction of the graft height in a 3- to 6-year healing period after maxillary sinus augmentation. The healing period and the amount of graft material influenced the resorption of BCP.
The osteogenic efficacy of BMP-2 on the regeneration of peri-implant bone defects was not detectable after 16 weeks regardless of the carrier materials.
The increase in soft-tissue dimensions for 1 year was similar between the two groups. The mucosal contour increase was larger when the surgery was conducted in a more contained defect, and this was not influenced by the type of BCP.
Due to the small sample size, this pilot study remains inconclusive. Within the limitations of the study, the use of CM and/or BS did not appear to have an additional benefit on lateral bone augmentation of peri-implant defect with TM.
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