Sungkyunkwan University · Medicine
Professor Jee-Heon Jeong's research lab specializes in regenerative medicine and cellular therapy, with a primary focus on enhancing the therapeutic efficacy of mesenchymal stromal cells (MSCs). The lab investigates the molecular mechanisms underlying the improved survival and anti-inflammatory properties of 3D-cultured MSCs, particularly through the regulation of autophagy and reactive oxygen species (ROS) homeostasis. By exploring the role of the tumor microenvironment and cellular stress responses, the lab aims to develop advanced cell-based therapies for inflammatory and degenerative diseases. Their work bridges stem cell biology, cellular metabolism, and translational medicine to improve clinical outcomes in regenerative therapy.
Figures are computed from collected data and may differ slightly.
Mesenchymal stromal cells (MSCs) have received attention as promising therapeutic agents for the treatment of various diseases. However, poor post-transplantation viability is a major hurdle in MSC-based therapy, despite encouraging results in many inflammatory disorders. Recently, three dimensional (3D)-cultured MSCs (MSC<sub>3D</sub>) were shown to have higher cell survival and enhanced anti-inflammatory effects, although the underlying mechanisms have not yet been elucidated. In this study, w
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