Pohang University of Science and Technology · Biochemistry, Genetics and Molecular Biology
Professor Jeong Wook Lee's research lab specializes in bioengineering and synthetic biology, focusing on the development of advanced biosensors, nucleic acid diagnostics, and metabolic engineering for sustainable bioproduction. The lab integrates systems biology, omics technologies, and materials science to engineer microorganisms—particularly *E. coli*—for efficient production of high-value compounds such as violacein and succinic acid. A key research direction involves designing point-of-care diagnostic platforms using paper-based and isothermal amplification technologies for rapid, sensitive detection of RNA viruses. Additionally, the lab develops functional nanomaterials, including superhydrophobic and antifogging coatings, for applications in environmental filtration and biomedical devices.
Figures are computed from collected data and may differ slightly.
The raw data files and the source codes of our experiments are available at: https://github.com/jhjeong0702/dna-storage.
Mannheimia succiniciproducens MBEL55E isolated from bovine rumen is an industrially important bacterium as an efficient succinic acid producer. Recently, its full genome sequence was determined. In the present study, we analyzed the M. succiniciproducens proteome based on the genome information using 2-DE and MS. We established proteome reference map of M. succiniciproducens by analyzing whole cellular proteins, membrane proteins, and secreted proteins. More than 200 proteins were identified and
A rapid, sensitive and simple point-of-care (POC) nucleic acid diagnostic test is needed to prevent spread of infectious diseases. Paper-based toehold reaction, a recently emerged colorimetric POC nucleic acid diagnostic test, has been widely used for pathogen detection and microbiome profiling. Here, we introduce an amplification method called reverse transcription loop-mediated amplification (RT-LAMP) prior to the toehold reaction and modify it to enable more sensitive and faster colorimetric
In the last few decades, numerous studies have focused on designing suitable hydrophilic materials to inhibit surface-induced fog or frost under extreme conditions. As fogging and condensation frosting on a film involves molecular interaction with water prior to forming discrete droplets on the surface, it is essential to control the extent of a film to strongly bind with water molecules for antifogging coatings. While the water contact angle measurement is commonly used to probe the hydrophilic
Violacein is a naturally occurring purple pigment, widely used in cosmetics and has potent antibacterial and antiviral properties. Violacein can be produced from tryptophan, consequently sufficient tryptophan biosynthesis is the key to violacein production. However, the complicated biosynthetic pathways and regulatory mechanisms often make the tryptophan overproduction challenging in <i>Escherichia coli</i>. In this study, we used the adaptive laboratory evolution (ALE) strategy to improve viola
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