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Ji Ye Lee

Seoul National University · Medicine

About the Lab

Professor Ji Ye Lee's research lab specializes in diagnostic and molecular imaging of thyroid diseases, with a strong focus on improving the accuracy of ultrasound-based diagnosis for thyroid nodules and lymph node metastasis. The lab investigates advanced ultrasound techniques such as Superb Microvascular Imaging (SMI) and contrast-enhanced ultrasound to enhance the characterization of thyroid lesions and cervical lymph nodes. Their work also explores the long-term safety of gadolinium-based contrast agents and contributes to evidence-based imaging guidelines for thyroid cancer management. The lab emphasizes clinical translation, aiming to optimize active surveillance strategies for low-risk thyroid cancer through radiological biomarkers.

ultrasound elastographylymph node metastasisthyroid imagingSuperb Microvascular Imagingactive surveillance

Research Overview

Papers
148
Total Citations
1,894
Papers (5y)
80
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
80total
2022
2023
2024
2025
2026
Citations per year (5y)
541total
20222023202420252026

Selected Papers

15
1
Review|80 citations·2021
2020 Imaging Guidelines for Thyroid Nodules and Differentiated Thyroid Cancer: Korean Society of Thyroid Radiology
Ji Ye Lee, Jung Hwan Baek, Eun Ju Ha, Jin Yong Sung, Jung Hee Shin, Ji‐hoon Kim, Min Kyoung Lee, So Lyung Jung, Young Hen Lee, Hye Shin Ahn, Jung Hyun Yoon, Yoon Jung Choi
SJR Q1FWCI 8.8Korean Journal of RadiologyOA

Imaging plays a key role in the diagnosis and characterization of thyroid diseases, and the information provided by imaging studies is essential for management planning. A referral guideline for imaging studies may help physicians make reasonable decisions and minimize the number of unnecessary examinations. The Korean Society of Thyroid Radiology (KSThR) developed imaging guidelines for thyroid nodules and differentiated thyroid cancer using an adaptation process through a collaboration between

Endocrinology, Diabetes and MetabolismMedicine
2
Article|41 citations·2016
Comprehensive chemical profiling of Pinellia species tuber and processed Pinellia tuber by gas chromatography–mass spectrometry and liquid chromatography–atmospheric pressure chemical ionization–tandem mass spectrometry
Ji Ye Lee, Na Hyun Park, Wonwoong Lee, Eun Hye Kim, Young Ho Jin, Eun Kyung Seo, Jongki Hong
SJR Q1FWCI 2.6Journal of Chromatography A
PharmacologyPharmacology, Toxicology and Pharmaceutics
3
Article|41 citations·2019
Ultrasound malignancy risk stratification of thyroid nodules based on the degree of hypoechogenicity and echotexture
Ji Ye Lee, Dong Gyu Na, So Jin Yoon, Hye Yun Gwon, Wooyul Paik, Taeeun Kim, Jin Yub Kim
SJR Q1FWCI 3.2European Radiology
Endocrinology, Diabetes and MetabolismMedicine
4
Article|40 citations·2019
Differentiation Between Malignant and Benign Lymph Nodes: Role of Superb Microvascular Imaging in the Evaluation of Cervical Lymph Nodes
Joo Kyung Sim, Ji Ye Lee, Hyun Sook Hong
SJR Q2FWCI 2.7Journal of Ultrasound in Medicine

Superb Microvascular Imaging yields more detailed information about nodal vessels than does PDUS by enabling visualization of small nodal vessels. Superb Microvascular Imaging is useful and feasible for differentiating between malignant and benign cervical LNs.

Critical Care and Intensive Care MedicineMedicine
5
Article|34 citations·2017
Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients
Ji Ye Lee, Ji Eun Park, Ho Sung Kim, Seon‐Ok Kim, Joo Young Oh, Woo Hyun Shim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim
SJR Q1FWCI 2.3PLoS ONEOA

Multiple repeated administrations of MICA were not associated with increased T1 signal intensity in deep brain nuclei suggestive of Gd deposition in patients with normal renal function.

Materials ChemistryMaterials Science
6
Article|28 citations·2023
US Predictors of Papillary Thyroid Microcarcinoma Progression at Active Surveillance
Ji Ye Lee, Ji‐hoon Kim, Yeo Koon Kim, Chang Yoon Lee, Eun Kyung Lee, Jae Hoon Moon, Hoon Choi, Yul Hwangbo, Sun Wook Cho, Su‐jin Kim, Kyu Eun Lee, Do Joon Park
SJR Q1FWCI 5.6Radiology

Background Active surveillance (AS) is an accepted strategy for patients with low-risk papillary thyroid microcarcinoma (PTMC). While previous studies have evaluated the prognostic value of US features, results have been inconsistent. Purpose To determine if US features can help predict tumor progression in patients with low-risk PTMC undergoing AS. Materials and Methods This prospective study enrolled 1177 participants with PTMC from three hospitals between June 2016 and January 2021. Participa

Endocrinology, Diabetes and MetabolismMedicine
7
Article|27 citations·2020
The Value of Microvascular Imaging for Triaging Indeterminate Cervical Lymph Nodes in Patients with Papillary Thyroid Carcinoma
Seongyong Lee, Ji Ye Lee, Ra Gyoung Yoon, Ji‐hoon Kim, Hyun Sook Hong
SJR Q1FWCI 1.8CancersOA

Assessment of lymph node (LN) status in patients with papillary thyroid carcinoma (PTC) is often troublesome because of cervical LNs with indeterminate US (ultrasound) features. We aimed to explore whether Superb Microvascular Imaging (SMI) could be helpful for distinguishing metastasis from indeterminate LNs when combined with power Doppler US (PDUS). From 353 consecutive patients with PTC, LNs characterized as indeterminate by PDUS were evaluated by SMI to distinguish them from metastasis. Ind

Endocrinology, Diabetes and MetabolismMedicine
8
Article|25 citations·2022
Validation of Ultrasound Risk Stratification Systems for Cervical Lymph Node Metastasis in Patients with Thyroid Cancer
Ji Ye Lee, Roh‐Eul Yoo, Jung Hyo Rhim, Kyung Hoon Lee, Kyu Sung Choi, Inpyeong Hwang, Koung Mi Kang, Ji‐hoon Kim
SJR Q1FWCI 3.3CancersOA

A malignancy risk stratification system (RSS) for cervical lymph nodes (LNs) has not been fully established. This study aimed to validate the current RSS for the diagnosis of cervical LN metastasis in thyroid cancer. In total, 346 LNs from 282 consecutive patients between December 2006 and June 2015 were included. We determined the malignancy risk of each ultrasound (US) feature and performed univariable and multivariable logistic regression analyses. Each risk category from the Korean Society o

Endocrinology, Diabetes and MetabolismMedicine
9
Article|21 citations·2012
Importance of membrane selection in the development of immunochromatographic assays for low-molecular weight compounds
Ji Ye Lee, Young Ah Kim, Mi Yeon Kim, Yong Tae Lee, Bruce D. Hammock, Hye Sung Lee
SJR Q1FWCI 1.9Analytica Chimica Acta
Biomedical EngineeringEngineering
10
Article|21 citations·2019
Detection of Local Recurrence in Patients with Head and Neck Squamous Cell Carcinoma Using Voxel-Based Color Maps of Initial and Final Area under the Curve Values Derived from DCE-MRI
Ji Ye Lee, Kai‐Lun Cheng, Jeong Hyun Lee, Young Jun Choi, H.W. Kim, Yu Sub Sung, Sae Rom Chung, Kyeong Hwa Ryu, Mi Sun Chung, Sang Yoon Kim, Sang-wook Lee, Jung Hwan Baek
SJR Q1FWCI 2.0American Journal of NeuroradiologyOA

Adding voxel-based color maps of initial and final 90-second time-signal intensity areas under the curve from dynamic contrast-enhanced MR imaging to conventional MR imaging increases the diagnostic accuracy to detect local recurrence in head and neck squamous cell carcinoma by improving the specificity without sacrificing the sensitivity.

OtorhinolaryngologyMedicine
11
Article|19 citations·2015
Multidetector CT angiography in the diagnosis and classification of carotid–cavernous fistula
Ji Ye Lee, Cheolkyu Jung, Yon Kwon Ihn, Dong Joon Kim, S O Seong, B.J. Kwon
SJR Q2FWCI 0.4Clinical Radiology
NeurologyMedicine
12
Article|15 citations·2018
Dehiscent high-riding jugular bulb presenting as conductive hearing loss
Young Hoon Koo, Ji Ye Lee, Jong Dae Lee, Hyun Sook Hong
SJR Q3FWCI 0.8MedicineOA

Although most of jugular bulb anomalies are asymptomatic, patients may present with conductive hearing loss due to the interference of sound transmission mechanics.

NeurologyNeuroscience
13
Article|15 citations·2019
Permeability measurement using dynamic susceptibility contrast magnetic resonance imaging enhances differential diagnosis of primary central nervous system lymphoma from glioblastoma
Ji Ye Lee, Atle Bjørnerud, Ji Eun Park, Bo Eun Lee, Joo Hyun Kim, Ho Sung Kim
SJR Q1FWCI 1.0European Radiology
Radiology, Nuclear Medicine and ImagingMedicine
14
Article|14 citations·2022
Malignancy risk stratification of thyroid nodules according to echotexture and degree of hypoechogenicity: a retrospective multicenter validation study
Ji Ye Lee, Chang Yoon Lee, Inpyeong Hwang, Sung‐Hye You, Sun‐Won Park, Boeun Lee, Ra Gyoung Yoon, Younghee Yim, Ji‐hoon Kim, Dong Gyu Na
SJR Q1FWCI 1.8Scientific ReportsOA

Various risk stratification systems show discrepancies in the ultrasound lexicon of nodule echotexture and hypoechogenicity. This study aimed to determine the malignancy risk of thyroid nodules according to their echotexture and degree of hypoechogenicity. From June to September 2015, we retrospectively evaluated 5601 thyroid nodules with final diagnoses from 26 institutions. Nodules were stratified according to the echotexture (homogeneous vs. heterogeneous) and degree of hypoechogenicity (mild

Endocrinology, Diabetes and MetabolismMedicine
15
Article|13 citations·2017
Joint approach based on clinical and imaging features to distinguish non-neoplastic from neoplastic pituitary stalk lesions
Ji Ye Lee, Ji Eun Park, Woo Hyun Shim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim, Jeong Hoon Kim, Ho Sung Kim
SJR Q1FWCI 0.7PLoS ONEOA

The joint diagnostic approach based on clinical and imaging-based factors robustly distinguished non-NPSLs from NPSLs. This approach could guide treatment strategies and prevent unnecessary surgery in patients with non-NPSL.

Endocrinology, Diabetes and MetabolismMedicine

Research Areas

Endocrinology, Diabetes and MetabolismRadiology, Nuclear Medicine and ImagingNeurologyGeneticsBiochemistryOtorhinolaryngology

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