Sungkyunkwan University · Environmental Science
Professor Jin-Sol Lee's research lab focuses on the impacts of environmental stressors—particularly ocean acidification and metal pollutants—on aquatic invertebrates, with a strong emphasis on rotifers as model organisms. The lab investigates molecular defense mechanisms, including glutathione S-transferases and mitochondrial genome organization, to understand oxidative stress responses and multigenerational adaptation. Additionally, the lab explores data-driven approaches in machine learning, particularly open-set recognition and data-dependent capacity analysis in neural networks, to address unknown-class detection in real-world AI applications. These interdisciplinary efforts bridge environmental toxicology and computational intelligence, aiming to uncover biological resilience and improve model robustness in complex systems.
Figures are computed from collected data and may differ slightly.
Ocean acidification (OA) is caused by changes in ocean carbon chemistry due to increased atmospheric <i>p</i>CO<sub>2</sub> and is predicted to have deleterious effects on marine ecosystems. While the potential impacts of OA on many marine species have been studied, the multigenerational effects on asexual organisms remain unknown. We found that low seawater pH induced oxidative stress and DNA damage, decreasing growth rates, fecundity, and lifespans in the parental generation, whereas deleterio
Glutathione S-transferases (GSTs) play an important role in phase II of detoxification to protect cells in response to oxidative stress generated by exogenous toxicants. Despite their important role in defense, studies on invertebrate GSTs have mainly focused on identification and characterization. Here, we isolated omega and sigma classes of GSTs from the freshwater rotifer Brachionus calyciflorus and the marine rotifer Brachionus koreanus and explored their antioxidant function in response to
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