Yonsei University · Medicine
Professor Jin Woo Chang's research lab specializes in the development and clinical application of magnetic resonance-guided focused ultrasound (MRgFUS) for the treatment of movement disorders. The lab focuses on stereotactic ablation of specific brain targets—such as the thalamus and globus pallidus—to treat conditions like essential tremor and Parkinson’s disease-related dyskinesia. Their work emphasizes long-term efficacy, safety, and the optimization of thermal lesioning techniques, with a strong commitment to translational research and patient-centered outcomes. The lab also investigates the technical and biological limitations of MRgFUS, particularly in achieving consistent lesion formation.
Figures are computed from collected data and may differ slightly.
Tremor suppression after MRgFUS thalamotomy for ET is stably maintained at 2 years. Latent or delayed complications do not develop after treatment. Ann Neurol 2018;83:107-114.
Magnetic resonance-guided focused ultrasound thalamotomy exhibits sustained clinical efficacy 4 years after the treatment of intractable essential tremor. Adverse events are generally transient. A large cohort of patients who have undergone magnetic resonance-guided focused ultrasound thalamotomy with longer follow-up is needed to confirm our findings. © 2019 International Parkinson and Movement Disorder Society.
In the present study, which marks the first Phase I pilot study of unilateral MRgFUS pallidotomy for parkinsonian dyskinesia, the authors demonstrated the efficacy of pallidal lesioning using MRgFUS and certain limitations that are unavoidably associated with incomplete thermal lesioning due to technical issues. Further investigation and long-term follow-up are necessary to validate the use of MRgFUS in clinical practice.Clinical trial registration no.: NCT02003248 (clinicaltrials.gov).
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