Jin-Woo Park

About half of all patients can expect recovery from pancreatectomy after 6 months, but those with risk factors need more careful follow-up and supportive management.

Novel vinylsulfone cyanine dyes (em. 550-850 nm) were designed and synthesized for fluorescent labeling of biomolecules via 1,2-addition reaction in aqueous conditions. Due to the virtue of chemical structures of both fluorophore and reactive group, these dyes could be significantly stable and reactive in various aqueous/organic conditions. A wide variety of pH, temperature, buffer concentration, and protein were tested for the optimal labeling condition.

The need for an efficacious and safe oral anticoagulant that does not require monitoring has been largely unmet. Many efforts have centered on preparing orally available heparin to improve patient compliance. In this study, novel orally active heparin derivatives (LHD), i.e. low molecular weight heparin (LMWH) conjugated with deoxycholic acid (DOCA), were evaluated in vitro and in vivo for their enhancement effect of oral heparin absorption. After oral administration of 10 mg/kg of water-soluble

This study suggests that detection of p16 expression by immunohistochemistry can be used as a useful surrogate test to predict prognosis, especially in IDH-mutant astrocytoma patients.

The oseltamivir-resistant neuraminidase mutant, His274Tyr (H274Y), has recently been identified in humans. The objective of our present research is to elucidate the origin of resistance of the H274Y mutation to oseltamivir (OTV) at the molecular level via molecular dynamics simulation. For this purpose, the binding free energies of OTV with the wild-type N1 subtype and with the H274Y mutant were calculated using the linear interaction energy method. The nonbonded interaction energies between OTV

The adsorption structures and diffusion of transition-metal (TM) adatoms on defect-free MgO(001) surfaces were investigated in this study by using ab initio electronic structure calculations based on the density functional theory. The preferential adsorption of TM on top of a surface oxygen atom was found, which coincides with the results of previous works. The surface diffusion occurred along the channel that passed through a hollow site and the energy barriers ranged from 0.12 to 0.83 eV. We a

The goal of the methylation classifier in brain tumor classification is to accurately classify tumors based on their methylation profiles. Accurate brain tumor diagnosis is the first step for healthcare professionals to predict tumor prognosis and establish personalized treatment plans for patients. The methylation classifier can be used to perform classification on tumor samples with diagnostic difficulties due to ambiguous histology or mismatch between histopathology and molecular signatures,

Advances in biotechnology, gene manipulation, and protein engineering for macromolecule drugs, such as insulin, parathyroid hormone (PTH), calcitonin, human growth hormone, erythropoietin (EPO), and peptide YY (PYY) allow commercial production in large scale for diverse therapeutic uses. Other macromolecules, such as mucopolysaccharide heparin, have expanded markets through improvements in their pharmacokinetic and pharmacological effects. However, most products are available only as injectable

This study describes wire electrical discharge machining (WEDM) of carbon nanofibers (CNFs) in air. Since EDM is able to machine any conductive material, it can be used to machine CNFs without causing physical damage. WEDM was applied for leveling and patterning of CNF mats, which improves the performance of field emission of CNFs. For WEDM, a wire jig system as well as debris-removing system was developed. The machining characteristics such as the effect of voltage and capacitance were investig

Purpose: To investigate the anti-aging properties of callus extract from Pyrus pyrifolia var. culta with skin regeneration and lightening activities.Methods: Callus extract of P. pyrifolia var. culta was produced on Murashige and Skoog (MS) medium supplemented with picloram, followed by extraction of the callus biomass in phosphate-buffered saline. The anti-oxidant activity of the extract was assessed using the DPPH free radical-scavenging assay. Inhibition of skin pigmentation by callus extract