Hanyang University · Engineering
Professor Jin-Kuk Kim's research lab specializes in the development of precision therapeutics for rare and genetic diseases, with a focus on splice-switching antisense oligonucleotides (ASOs) for personalized medicine. The lab integrates genomics, systems biology, and computational modeling to identify novel therapeutic targets and design patient-specific drugs, as demonstrated in the clinical translation of milasen for a fatal neurodegenerative disorder. They also apply advanced systems engineering to optimize industrial processes, particularly in carbon capture and cooling water networks, emphasizing sustainability and efficiency. Their interdisciplinary approach bridges biomedical innovation with process systems engineering to address critical challenges in healthcare and energy sustainability.
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Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the rational design, testing, and manufacture of milasen, a splice-modulating antisense oligonucleotide drug tailored to a particular patient. Proof-of-concept experiments in cell lines from the patient served as the basis for launching an "N-of-1" study of milasen within 1 year after f
Splice-switching antisense oligonucleotides (ASOs) could be used to treat a subset of individuals with genetic diseases<sup>1</sup>, but the systematic identification of such individuals remains a challenge. Here we performed whole-genome sequencing analyses to characterize genetic variation in 235 individuals (from 209 families) with ataxia-telangiectasia, a severely debilitating and life-threatening recessive genetic disorder<sup>2,3</sup>, yielding a complete molecular diagnosis in almost all
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor, yet with no targeted therapy with substantial survival benefit. Recent studies on solid tumors showed that fusion genes often play driver roles and are promising targets for pharmaceutical intervention. To survey potential fusion genes in GBMs, we analysed RNA-Seq data from 162 GBM patients available through The Cancer Genome Atlas (TCGA), and found that 3' exons of neurotrophic tyrosine kinase receptor type 1 (NTRK1, enco
Aqueous MEA-based CO2 capture is one of main technologies for CO2 capture. However, there are various different sources of flue gases from different industries which have different flow conditions. In particular the CO2 content is very important and it will have a critical impact on the associated design of CO2 capture processes. In this study a superstructure optimization methodology is applied to ranges of different flue gases found in non-power industries such as cement, steel and refinery pl
Abstract An automated approach from the systematic investigation of interactions between cooling‐tower performance and the cooling‐water network design was developed for retrofit design of cooling‐water systems. Introducing reuse of cooling water between different cooling duties enables cooling systems to be debottlenecked. The series arrangement of heat exchangers, however, results in a pressure drop increase because of the cooling water reuse. An optimization model for cooling‐water networks d
Cooling water systems and refrigeration systems are required to provide cold utility to chemical processes. Little attention has been placed on the structure and system interactions between cooling systems and processes. In this article, an integrated design and retrofit method for cooling systems is reviewed. For cooling water system design, a new design methodology has been developed for debottlenecking of cooling water systems. Reuse of cooling water between different cooling duties enables c
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