Kyung Hee University · Medicine
Professor Jong Hoon Ryu's research lab specializes in neuropharmacology and neuroinflammation, focusing on the therapeutic potential of natural compounds in neurological disorders. The lab investigates how bioactive phytochemicals, such as eupatilin and tanshinone I, modulate microglial activation and neuroinflammatory pathways to exert neuroprotective effects. Current research directions include elucidating the molecular mechanisms of these compounds in stroke (e.g., focal cerebral ischemia) and cognitive impairment models, particularly through modulation of intracellular signaling pathways like ERK. The lab also explores the role of microglia in neurodegenerative and neurodevelopmental conditions, aiming to develop natural product-based therapies.
Figures are computed from collected data and may differ slightly.
Microglial activation and its-driven neuroinflammation are characteristic pathogenetic features of neurodiseases, including focal cerebral ischemia. The Artemisia asiatica (Asteraceae) extract and its active component, eupatilin, are well-known to reduce inflammatory responses. But the therapeutic potential of eupatilin against focal cerebral ischemia is not known, along with its anti-inflammatory activities on activated microglia. In this study, we investigated the neuroprotective effect of eup
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