Sungkyunkwan University · Medicine
Professor Kangmo Ahn's research lab specializes in environmental health and allergic diseases, focusing on the impact of air pollution and environmental allergens on skin and respiratory health. The lab investigates the molecular mechanisms linking particulate matter (PM2.5) and phthalates to impaired skin barrier function and allergic sensitization, particularly in children. Key research directions include identifying novel allergens in common foods like pistachios and assessing the epidemiological prevalence of asthma, eczema, and food allergies in Korean populations. The lab integrates clinical, molecular, and population-based approaches to understand environmental triggers of atopy and allergic inflammation.
Figures are computed from collected data and may differ slightly.
The molecular mechanisms that underlie the detrimental effects of particulate matter (PM) on skin barrier function are poorly understood. In this study, the effects of PM2.5 on filaggrin (FLG) and skin barrier function were investigated in vitro and in vivo. The levels of FLG degradation products, including pyrrolidone carboxylic acid, urocanic acid (UCA), and cis/trans-UCA, were significantly decreased in skin tape stripping samples of study subjects when they moved from Denver, an area with lo
Exposure to meteorological variables and air pollutants are associated with AD symptoms in young children.
Novel allergens in pistachio, Pis v 1 and Pis v 2, which belong to 2S albumin and 11S globulin family, respectively, were isolated and the genes encoding these allergens were identified.
T o investigate the prevalence of asthma, allergic rhinitis, and eczema, we did a cross-sectional survey of 4,003 children aged 6-7 years (students in the 1st year of elementary school) and 4,112 students aged 13-14 years (students in the 1st year of middle school), chosen from a random sample of 45 primary and 40 middle schools across the nation. The Korean-translated modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used in this survey.
Phthalates, especially DEHP, may worsen pulmonary function and airway inflammation in asthmatic children. To control asthma symptoms, exposure to phthalates needs to be avoided.
Although the prevalence and causes of food allergy (FA) vary by geographic location, large well-designed epidemiological studies in Asia are lacking. The purpose of this study was to evaluate the prevalence of immediate-type FA in the general population of Korean schoolchildren. A population-based, cross-sectional study was conducted in 2010 using a stratified two-stage cluster-sampling design. In this survey, children aged 6-7 years and 12-13 years were randomly selected, and the presence of FA
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