Hokkaido University · Medicine
Kazuki Shimizu 교수의 연구실은 바이오폴리머 및 생체재료 분야에서 활발한 연구를 수행하고 있습니다. 특히 폴리-γ-글루타믹산(PGA)의 미생물 합성 메커니즘과 염 농도가 생산성 및 입체화학적 특성에 미치는 영향을 중심으로 한 생물합성 기술 개발에 중점을 두고 있습니다. 또한, 음향장의 고속 촬영 및 디지털 홀로그래피 기반 음향 이미징 기술을 활용한 신소재 및 신기기 개발도 함께 진행하고 있습니다. 이는 생물기반 고분자와 첨단 음향 측정 기술의 융합 연구를 목표로 합니다.
Figures are computed from collected data and may differ slightly.
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While the epidemiological impact of the coronavirus disease 2019 (COVID-19) pandemic has been relatively moderate in East-Asian countries, the pandemic has significantly impacted on citizens' lives and livelihoods, and Japan is no exception. In the early phase of the COVID-19 pandemic, Japan managed unprecedented quarantines and realized the difficulty of controlling COVID-19, finally recording a relatively high number of deaths per million in the Western Pacific region. However, scant research
Sound field imaging techniques have been found very useful for acoustic designs. Building on this idea, innovative techniques are needed and presented in this paper, where we report on developed imaging of the sound field radiated from speakers by parallel phase-shifting digital holography. We adopted an ultrasonic wave radiated from a speaker for an object. The phase distribution of the light wave was modulated by the sound field radiated from the speaker. The modulated phase distribution was r
Poly-gamma-glutamate (PGA) is a chiral polyamide material that possesses a nylon-like backbone, a bionylon polymer. We examined the PGA productivity of Bacillus megaterium and found NaCl-responsive PGA production in the bacterium. In the system of B. megaterium, salt would be significant in controlling the yield, molecular size, and stereochemistry of bionylon.
Compared with other G7 countries, Japan has been relatively successful in mitigating the spread of covid-19. 1However, Japan has the second worst record in the Western Pacific region, with over 40 deaths per million population over the course of the crisis. 1 Japan entered a second state of emergency in January 2021 2 following an exponential rise in confirmed cases of covid-19. 1A clear, consistent exit strategy is now critical.Despite shortcomings in its early covid-19 response, 3 4 Japan fail
The 2020 summer Olympic and Paralympic Games in Tokyo were postponed to July-September 2021 due to the coronavirus disease 2019 (COVID-19) pandemic. While COVID-19 has emerged as a monumental health threat for mass gathering events, heat illness must be acknowledged as a potentially large health threat for maintaining health services. We examined the number of COVID-19 admissions and the Tokyo rule for emergency medical care, in Tokyo, from March to September 2020, and investigated the weekly nu
Very-KIND/Kndc1/KIAA1768 (v-KIND) is a brain-specific Ras guanine nucleotide exchange factor carrying two sets of the kinase non-catalytic C-lobe domain (KIND), and is predominantly expressed in cerebellar granule cells. Here, we report the impact of v-KIND deficiency on dendritic and synaptic growth in cerebellar granule cells in v-KIND knockout (KO) mice. Furthermore, we evaluate motor function in these animals. The gross anatomy of the cerebellum, including the cerebellar lobules, layered cer
The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted essential health services. Simultaneously, it has created opportunities for citizens to raise awareness of personal hygiene, mask wearing, and other preventive measures. This brief report aims to clarify the epidemiological trends of measles and rubella in Japan and to explore future challenges for controlling these diseases during and after the COVID-19 pandemic. Although Japan eliminated measles in 2015, the number of
A single index case gave rise to a total of 38 secondary cases, 33 in Japan and five in China, Taiwan, China. Subsequent chains of transmission were observed in highly vaccinated populations in both Japan and China, Taiwan, China. The effective reproduction number of the second generation was > 1 for both Japan and China, Taiwan, China. In Japan, the reproduction number was estimated to be < 1 during the third generation. Vaccination of susceptible individuals is essential to prevent secondary a
Complementary synthesis of two kinds of fluorinated bridged biphenyls has been developed by the combination of oxidative carbon–carbon bond formation and deoxyfluorination.
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