The University of Osaka · Medicine
Professor Kazuko Kaneda-Nakashima's research lab specializes in targeted alpha therapy (TAT) for cancer treatment, focusing on the development of radiolabeled compounds that selectively deliver alpha-emitting radionuclides to tumor cells. The lab investigates tumor-specific transporters such as LAT1 and fibroblast activation protein (FAP) as molecular targets, designing and optimizing novel radioligands like 211At-labeled α-methyl-l-tyrosine and FAPI derivatives for precise tumor imaging and therapy. Their work emphasizes improving tumor targeting, therapeutic efficacy, and safety through rational molecular design and in vitro/in vivo evaluation. The lab also explores the biological mechanisms of allergic inflammation, particularly the role of zinc as a novel mediator in IgE-dependent signaling in mast cells.
Figures are computed from collected data and may differ slightly.
α-Methyl-l-tyrosine (AMT) has a high affinity for the cancer-specific l-type amino acid transporter 1 (LAT1). Therefore, we established an anti-cancer therapy, with <sup>211</sup> At-labeled α-methyl-l-tyrosine (<sup>211</sup> At-AAMT) as a carrier of <sup>211</sup> At into tumors. <sup>211</sup> At-AAMT had high affinity for LAT1, inhibited tumor cell growth, and induced DNA double-stranded breaks in vitro. We evaluated the accumulation of <sup>211</sup> At-AAMT in vivo and the role of LAT1. Tr
Fibroblast activation proteins (FAP) are overexpressed in the tumor stroma and have received attention as target molecules for radionuclide therapy. The FAP inhibitor (FAPI) is used as a probe to deliver nuclides to cancer tissues. In this study, we designed and synthesized four novel <sup>211</sup>At-FAPI(s) possessing polyethylene glycol (PEG) linkers between the FAP-targeting and <sup>211</sup>At-attaching moieties. <sup>211</sup>At-FAPI(s) and piperazine (PIP) linker FAPI exhibited distinct
Isocyanates are very useful chemicals, and these are important for our daily life. Various products, especially urethane resin, are made from these chemicals. There is no substitute for isocyanates at the present. Isocyanates are patent agents to provoke immunological responses. This article deals with the case reports of hypersensitivity pneumonitis (HP) induced by isocyanates in Japan. It is said that HP is one of the rare diseases induced by isocyanate with very low frequency so far in the wo
Although polymorphisms in RIP2 are not likely to be associated with the development of asthma, the genetic variants might contribute to asthma severity in the Japanese population.
Our results indicate that IgE-dependent Zn release from human MCs involves signaling cascades that are distinct from those of degranulation. Thus, Zn may have a unique function as a mediator of allergic inflammation.
Currently, targeted alpha therapy (TAT) is a new therapy involving the administration of a therapeutic drug that combines a substance of α-emitting nuclides that kill cancer cells and a drug that selectively accumulates in cancer cells. It is known to be effective against cancers that are difficult to treat with existing methods, such as cancer cells that are widely spread throughout the whole body, and there are high expectations for its early clinical implementation. The nuclides for TAT, incl
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