The University of Osaka · Medicine
Professor Kenichi Todo's research lab specializes in cerebrovascular diseases, with a focus on the mechanisms, diagnosis, and treatment of ischemic stroke. The lab investigates arrhythmias such as premature atrial contractions as potential hidden triggers of cardioembolic stroke, explores the role of collateral circulation in stroke outcomes, and examines rare but significant causes of embolic stroke, including small pulmonary arteriovenous malformings. Their work bridges clinical neurology and experimental stroke models, aiming to improve early diagnosis and expand therapeutic options for stroke patients.
Figures are computed from collected data and may differ slightly.
Based on our CT findings, stroke at awakening seems to be developing shortly before in a large subset of patients, making them potential candidates for acute stroke therapies.
After CCA occlusion, GM-CSF treatment enhanced leptomeningeal collateral growth and decreased the infarct size after MCA occlusion in mice.
We report a case of recurrent paradoxical brain embolism mediated through a small pulmonary arteriovenous malformation (PAVM) with a 1.8-mm-diameter feeding artery. In this case, the further recurrent stroke was prevented successfully by PAVM embolization. Although embolization therapy is currently recommended only for PAVMs with feeding arteries greater than 3 mm in diameter, the therapy may be needed also in the smaller PAVMs.
Our data suggest that frequent PAC should be regarded as a masked type of paroxysmal atrial fibrillation and should be included in one of the causes of cardioembolic stroke.
High frequency of PACs in cryptogenic stroke may be a strong predictor of AF detected by ICM.
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