Hokkaido University · Chemistry
Professor Kenji Monde's research lab specializes in the structural elucidation and biosynthesis of natural products, with a focus on complex organic molecules such as phytoalexins, organochlorine compounds, and carbohydrates. The lab uniquely combines advanced spectroscopic techniques—particularly vibrational circular dichroism (VCD)—with theoretical calculations and biochemical studies to determine absolute configurations and reaction mechanisms in solution. A key contribution is the development of the 'glycoside band' in VCD spectroscopy, enabling precise analysis of carbohydrate anomeric configurations. The lab also investigates the enzymatic biosynthesis of natural pesticides, especially in plants like *Lilium maximowiczii*, revealing novel chlorination pathways in higher plants.
Figures are computed from collected data and may differ slightly.
Vibrational circular dichroism (VCD) technique successfully revealed the absolute configuration of the biased helix of perfluoroalkyl chains in solution with the aid of theoretical calculations, which was supported by an X-ray crystallographic study.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of Cruciferous PhytoalexinsKenji Monde, Mitsuo Takasugi, and Toshiyuki OhnishiCite this: J. Am. Chem. Soc. 1994, 116, 15, 6650–6657Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ja00094a021https://doi.org/10.1021/ja00094a021research-articleACS PublicationsRequest reuse permissionsArticle Views363Altmetric-Citations52LEARN ABOUT THESE METRICSAr
Seven chlorine-containing orcinol derivatives (2-8) and orcinol (9) have been isolated from diseased bulbs of the edible lily Lilium maximowiczii, and their structures have been elucidated. Six of the chlorinated orcinol derivatives (2, 4-8) showed antifungal activity. Because organochlorine compounds are rare in terrestrial higher plants, their biosynthetic origin was examined. These compounds were shown to be induced in intact bulb scales by UV irradiation or by inoculation with the pathogenic
The vibrational circular dichroism (VCD) technique was applied to carbohydrates and produced a glycoside characteristic VCD band, which was named the "glycoside band." It confirmed that this vibration was related to anomeric configurations of carbohydrates in the case of the d-series by means of isotope substitution. This band is defined as a negative, sharp, and intense VCD band at around 1145 cm-1, exhibited by d-sugars with an axial alpha-glycosidic linkage in the 4C1 conformation. As applica
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