Korea University · Biochemistry, Genetics and Molecular Biology
Professor Kwang-Won Lee's research lab focuses on bioactive natural products and their therapeutic applications, particularly in immunomodulation, mycotoxin toxicity, and metabolic disease prevention. The lab investigates bioactive compounds such as fucoidan, plant extracts, and essential fatty acids to understand their mechanisms in enhancing immune function, reducing oxidative stress, and lowering cholesterol. Key research directions include the development of natural immunostimulants, inhibitors of advanced glycation end-products (AGEs), and functional components from traditional medicinal plants and food sources. The lab integrates in vitro and in vivo models to evaluate the efficacy and safety of these compounds for potential clinical applications in diabetes, aging-related disorders, and liver diseases.
Figures are computed from collected data and may differ slightly.
Immunomodulation involves two mechanisms, immunostimulation and immunosuppression. It is a complex mechanism that regulates the pathophysiology and pathogenesis of various diseases affecting the immune system. Immunomodulators can be used as immunostimulators to reduce the side effects of drugs that induce immunosuppression. In this study, we characterized the chemical composition of high molecular weight fucoidan (HMWF) and low molecular weight fucoidan and compared their functions as natural k
In this paper, we consider K-user Y channels where K users simultaneously exchange messages with each other via an intermediate relay. Degrees of freedom (DOF) of Y channels with multiple antennas is not known in general. Investigation of the feasibility conditions of signal space alignment for network coding is an initial step for addressing this open problem. We verify that when user i with M-i antennas sends K-1 independent messages to the other users through a relay with N antennas and each
Ochratoxin A (OTA) is a widespread mycotoxin produced by several species of the genera <i>Aspergillus</i> and <i>Penicillium</i>. OTA exists in a variety of foods, including rice, oats, and coffee and is hepatotoxic, with a similar mode of action as aflatoxin B1. The precise mechanism of cytotoxicity is not yet known, but oxidative damage is suspected to contribute to its cytotoxic effects. In this study, human hepatocyte HepG2 cells were treated with various concentrations of OTA (5-500 nM) for
The glycation reaction involves a series of non-enzymatic reactions between the carbonyl group on reducing sugars and the amino group on proteins leading to the formation of advanced glycation end-products (AGEs), which are acknowledged to be involved in the pathogenesis of diabetic and aging-related complications. Consequently, the development of AGE inhibitors is considered to have therapeutic potential in patients with diabetes or age-related diseases. The preliminary results showed that a me
The aims of this study were to obtain concentrated pinolenic acid (5,9,12-18:3) from dietary Korean pine (Pinus koraiensis) nut oil by urea complexation and to investigate its cholesterol-lowering effect on the LDL-receptor activity of human hepatoma HepG2 cells. Pine nut oil was hydrolyzed to provide a low-pinolenic acid-containing FA extract (LPAFAE), followed by crystallization with different ratios of urea in ethanol (EtOH) or methanol (MeOH) as a solvent to produce a high-pinolenic acid-con
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