Sungkyunkwan University · Medicine
Professor Kyu Hyuck Chung's research lab specializes in bioactive natural products and their molecular mechanisms, with a focus on identifying and characterizing compounds from traditional herbs and synthetic chemicals that exert protective or toxic effects on human cells. The lab investigates the pathophysiological mechanisms of environmental pollutants—such as microplastics and guanidine-based disinfectants—on the respiratory and hepatic systems, particularly in relation to fibrosis and oxidative stress. Additionally, the lab explores the therapeutic potential of natural compounds in treating liver fibrosis and estrogen-related disorders through in vitro and in vivo models.
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Vector-based RNA interference (RNAi) has emerged as a valuable tool for analysis of gene function. We have developed new RNA polymerase II expression vectors for RNAi, designated SIBR vectors, based upon the non-coding RNA BIC. BIC contains the miR-155 microRNA (miRNA) precursor, and we find that expression of a short region of the third exon of mouse BIC is sufficient to produce miR-155 in mammalian cells. The SIBR vectors use a modified miR-155 precursor stem-loop and flanking BIC sequences to
The detection of high levels of microplastics in indoor and outdoor air has increased concerns regarding its toxic effects on the respiratory system. They are not easily degradable and can be deposited deep in the lungs. Although several studies have reported inhalation toxicities of microplastics, they are still controversial due to a lack of evidence. Herein, we evaluated the inhalation toxicities of three differently charged polystyrene microplastics (PS-MPs), the most abundant microplastics
Abstracts <b>Objective:</b> The major active ingredient of humidifier disinfectant, polyhexamethylene guanidine-phosphate (PHMG-P), caused hundreds of deaths with pulmonary fibrosis. However, structurally similar guanidine-based disinfectants are still in use in various fields. Moreover, as they are precursors of excellent antimicrobial compounds, new chemicals with guanidine-based structures have been synthesized and introduced. In this study, we evaluated pulmonary fibrotic responses induced b
Hepatic fibrosis is characterized by the abnormal deposition of extracellular matrix (ECM) proteins. During hepatic fibrogenesis, hepatic stellate cell (HSC) activation followed by chronic injuries is considered a key event in fibrogenesis, and activated HSCs are known to comprise approximately 90% of ECM-producing myofibroblasts. Here, we demonstrated that (-)-catechin-7-<i>O</i>-β-d-apiofuranoside (C7A) significantly inhibited HSC activation via blocking the signal transducer and activator of
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