Nagoya University · Medicine
Professor Mariko Kawamura's research lab focuses on translational oncology and neurodegenerative disease mechanisms, with a strong emphasis on improving diagnostic and therapeutic strategies for breast cancer and central nervous system disorders. The lab investigates advanced imaging techniques, such as MRI, to predict treatment response in breast cancer patients and optimize radiotherapy delivery through innovations like intraoperative radiation therapy (IORT) and immobilization techniques. Additionally, the lab explores systemic links between chronic infections—such as *Helicobacter pylori*—and neurodegenerative or cardiovascular diseases, highlighting the role of glymphatic system dysfunction in neurodegeneration. The research integrates clinical imaging, molecular mechanisms, and patient outcomes to advance precision medicine in oncology and neuroscience.
Figures are computed from collected data and may differ slightly.
The concept of the glymphatic system was proposed more than a decade ago as a mechanism for interstitial fluid flow and waste removal in the central nervous system. The function of the glymphatic system has been shown to be particularly activated during sleep. Dysfunction of the glymphatic system has been implicated in several neurodegenerative diseases. Noninvasive in vivo imaging of the glymphatic system is expected to be useful in elucidating the pathophysiology of these diseases. Currently,
It is reported that <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection may be linked to non-digestive tract diseases, such as arteriosclerosis including dyslipidemia, diabetes, obesity, hypertension, and cardiovascular disease. Therefore, we reviewed recent studies available in PubMed dealing with the mechanisms of arteriosclerosis due to <i>H. pylori</i> infection and the effects of <i>H. pylori</i> eradication. Conventional studies suggested that <i>H. pylori</i> infection may increase th
The first group of female Asian patients tolerated the treatment with IORT in this Phase I/II study and remained recurrence-free for more than 5 years after treatment. However, 24 % of the patients developed hypertrophic scarring, an event that is being further examined in our ongoing multi-center Phase II trial of IORT for early breast cancer.
Neoadjuvant chemotherapy (NAC) is the favored treatment of choice among locally advanced breast cancer patients because it significantly increases the possibility of breast-conserving surgery. However, for non-responders, an early prediction of response to NAC is essential. The purpose of this study was to determine whether an early prediction of response to NAC is possible using MRI. Eleven breast cancer patients (12 lesions) scheduled to receive NAC were recruited for this study. The patients
The use of an immobilizing bra reduced the setup margin for prone position fixation of breast tumors.
Our results suggest that the application of an SCCC regimen such as EP or IP as first-line chemotherapy for patients with locally advanced SCCC may play a key role in OS. These findings need to be validated in future nationwide, prospective clinical studies.
VPS is easy to shape and reproducible. The authors succeeded in demonstrating its safety and accuracy as a proton beam stopper.
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