Nagoya University · Medicine
마사후미 쿠즈야 교수의 연구실은 혈관 질환의 핵심 메커니즘인 염증과 세포외기질 변화에 초점을 맞춘 혈관생물학 연구를 수행하고 있습니다. 특히 마트릭스 금속단백질라아제(MMP-2)가 동맥경화증과 혈관 재구성 과정에서 세포 이동과 기질 파괴를 통해 병변 형성에 기여하는 메커니즘을 규명하고 있으며, 이는 혈관성 질환의 예방 및 치료 전략 개발에 기여하고자 합니다. 또한 항산화제의 세포보호 작용과 노인 돌봄 부담, 일상 활동 참여가 노인 사망률에 미치는 영향 등 노화와 관련된 생물학적·사회적 요인의 상호작용에 대해서도 연구를 확장하고 있습니다.
Figures are computed from collected data and may differ slightly.
MMP-2 contributes to the development of atherosclerosis in apoE(-/-) mice.
In a mouse carotid artery blood flow cessation model, MMP-2 contributes to intimal hyperplasia mainly through the SMC migration from the media into the intima by degrading and breaching the extracellular matrix proteins surrounding each cell and the internal elastic lamina.
Vascular remodeling, defined as lasting structural changes in the vessel wall in response to hemodynamic stimuli, plays a role in many (patho)physiological processes requiring cell migration and degradation of extracellular matrix(ECM). Matrix metalloproteinase(MMP) system can degrade most ECM components. Several lines of evidence support a role for MMP system components in the development and progression of atherosclerosis and restenosis after angioplasty. This review article focuses on the rol
Among the community-dwelling frail elderly, falls are associated with caregiver burden even when controlling for various possible confounding factors.
We evaluated the effect of the antioxidant, probucol, on the cytotoxic effects of oxidized low density lipoprotein (OX-LDL) or of cumene hydroperoxide (CumOOH) on cultured bovine endothelial cells (EC). The addition of CumOOH to EC caused the release of lactate dehydrogenase and the accumulation of thiobarbituric acid-reacting substances (TBARS), effects that were protected against by preincubation with either probucol or tocopherol. Similarly, preincubation of EC with those antioxidants protect
Among community-dwelling frail older people, day care service use two or more times per week was associated with 44% to 63% lower 21-month mortality.
Open papers in the app to read, cite, and organize with AI.
