Kyoto University · Medicine
Professor Masahiro Shiokawa's research lab focuses on the immunological and molecular mechanisms underlying autoimmune pancreatitis (AIP) and immunoglobulin G4-related disease (IgG4-RD), with a particular emphasis on identifying autoantigens such as laminin 511-E8 and understanding the pathogenic roles of IgG subtypes. The lab also investigates the links between autoimmune disorders and cancer, exploring AIP as a potential paraneoplastic syndrome, and examines the role of key molecules like PARP-1 in tumorigenesis and stem cell differentiation. Their work bridges autoimmunity, cancer biology, and molecular immunology, aiming to uncover novel diagnostic and therapeutic targets.
Figures are computed from collected data and may differ slightly.
Patients with AIP are at high risk of having various cancers. The highest risk for cancer in the first year after AIP diagnosis and absence of AIP relapse after successful treatment of the coexisting cancers suggest that AIP may develop as a paraneoplastic syndrome in some patients.
Autoimmune pancreatitis (AIP), a major manifestation of immunoglobulin G4-related disease (IgG4-RD), is an immune-mediated disorder, but the target autoantigens are still unknown. We previously reported that IgG in patients with AIP induces pancreatic injuries in mice by binding the extracellular matrix (ECM). In the current study, we identified an autoantibody against laminin 511-E8, a truncated laminin 511, one of the ECM proteins, in patients with AIP. Anti-laminin 511-E8 IgG was present in 2
IgG1 and IgG4 from patients with IgG4-RD have pathogenic activities through binding affected tissues in neonatal mice.
Accumulated evidence suggests that poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA repair, cell-death induction, differentiation and tumorigenesis. Parp-1 deficiency also induces trophoblast differentiation from mouse embryonic stem cells during teratocarcinoma-like tumor formation. To understand the relationship of PARP-1 dysfunction and development of germ cell tumors, we conducted a genetic analysis of the PARP-1 gene in human germ cell tumors. Sixteen surgical specimens of germ cel
Our findings highlight the context-dependent roles of HES1 in the adult pancreas and pancreatic cancer.
Ulcerative colitis (UC) is a multifactorial chronic disorder with a high prevalence worldwide. UC affects patients in all age groups; however, pediatric-onset UC is generally more severe than adult-onset UC.1Alatab S. et al.Lancet Gastroenterol Hepatol. 2020; 5: 17-30Abstract Full Text Full Text PDF PubMed Scopus (630) Google Scholar To avoid long-term unfavorable outcomes, such as growth failure, early and proper diagnosis with subsequent treatment is needed for pediatric UC patients. Gastroint
The prognosis of gallbladder cancer (GBC) remains poor, and a better understanding of GBC molecular mechanisms is important. Genome sequencing of human GBC has demonstrated that loss-of-function mutations of E74-like ETS transcription factor 3 (ELF3) are frequently observed, with ELF3 considered to be a tumour suppressor in GBC. To clarify the underlying molecular mechanisms by which ELF3 suppresses GBC development, we performed in vivo analysis using a combination of autochthonous and allograft
Our case is a first report of autoimmune pancreatitis with multiple masses within the pancreas which was pathologically diagnosed by endoscopic ultrasound-guided fine needle aspiration and treated by steroid. The masses disappeared by steroid therapy. Our case is informative to know that autoimmune pancreatitis sometimes exhibits multiple masses within the pancreas and to diagnose it without unnecessary surgery.
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